Background: Because of fear of skeletal complications, physicians often avoid referring patients with secondary bone cancer (SBC) to physical rehabilitation. However, there is little evidence on the risk of skeletalrelated events (SREs) and pathological fracture (PF) during rehabilitation therapies. Objective: To determine the risk of PF following physical rehabilitation in people with SBC. Design: Single-group, singlecentered interventional clinical trial. Setting: University-based outpatient rehabilitation clinic. Patients: Forty-eight patients with confirmed diagnosis of SBC were enrolled. Interventions: Participants were prescribed a multidisciplinary rehabilitation program. Participants and rehabilitation therapists were trained to detect and report symptoms that would indicate PF. Radiographs were used to confirm the presence of PF.
A fadiga relacionada ao câncer é um dos sintomas mais comuns entre pacientes com câncer, relatada em 70% a 100% desses pacientes resultando em uma redução significativa da qualidade de vida, funcionalidade e independência. O exercício físico tem sido identificado como um elemento central de reabilitação de muitas doenças crônicas como câncer, e cada vez mais evidências apoiam a tese de que a atividade física é uma intervenção útil, que pode ser utilizada em conjunto com terapias convencionais durante o tratamento da fadiga relacionada ao câncer. Objetivo: O objetivo deste estudo é avaliar o impacto de dois programas de exercício físico sobre os níveis de fadiga e desempenho físico de pacientes com câncer. Método: Relato de uma série consecutiva de 44 doentes adultos com doença neoplásica (sólido ou hematológicas), e diagnós-tico médico de fadiga, submetidos a dois diferentes programas de exercício físico. Todos os doentes foram avaliados quanto a desempenho físico com o uso do teste de caminhada de 6 minutos e avaliados quanto aos níveis de fadiga com o teste de Piper, antes e depois de 4 meses de atividade física supervisionada (exercícios aeróbicos isolados e treino de resistência combinado ao exercícios aeróbicos). Resultados: Após 16 semanas, os doentes que participaram do programa de exercícios aeróbicos ou que participaram do protocolo de exercício aeróbico combinado com anaeróbio, relataram níveis significativamente mais elevados do desempenho físico (6 minutos teste de caminhada, p = 0,0009 e p = 0,001, respectivamente) e níveis de fadiga significativamente menor (PFS-R, p = 0,003 e p = 0,002, respectivamente) do que no início do programa de exercícios. Conclusão: Estes resultados demonstram que tanto um protocolo de exercício aeróbico quanto de exercício aeróbico combinado com exercício anaeróbio apresentam melhora significativa do desempenho físico e dos níveis de fadiga de doentes oncológicos. Os dados deste estudo corroboram a literatura mostrando que a atividade física é uma estratégia eficaz para o tratamento da fadiga. Os resultados deste estudo confirmam que o exercício físico pode ser útil na reabilitação de sobreviventes de câncer, especialmente para pacientes com fadiga oncológica.Palavras-chave: aptidão física, exercício, fadiga, neoplasias, reabilitação ABSTRACTCancer-related fatigue is a common symptom in patients with cancer, which is experienced by 70% to 100% of these patients and brings some impairment of physical and mental performance, hinders their working or carrying out regular daily activities, and hence results in a substantial reduction of the quality of life. Physical exercise has consistently been identified as a central element of rehabilitation for many chronic diseases like cancer, and increasing evidence supports the contention that physical activity is a valuable intervention that can be utilized in conjunction with conventional therapies during CRF treatment. Objective: The aim of this study was to assess the impact of a program of physical exercise on fatigue levels and...
Cancer-related fatigue is a common symptom in patients with cancer, which is experienced by 70% to 100% of these patients and brings some impairment of physical and mental performance, hinders their working or carrying out regular daily activities, and hence results in a substantial reduction of the quality of life. Physical exercise has consistently been identified as a central element of rehabilitation for many chronic diseases like cancer, and increasing evidence supports the contention that physical activity is a valuable intervention that can be utilized in conjunction with conventional therapies during CRF treatment. Objective: The aim of this study was to assess the impact of a program of physical exercise on fatigue levels and physical performance of cancer patients. Method: A consecutive series of 44 adult patients with neoplastic disease (solid or hematological), with a medical diagnosis of fatigue, who were enrolled in an oncological treatment, with the ability to walk and willing to enter a rehabilitation program of exercise for at least 4 consecutive months. The exercise program was performed two times per week, each session lasting one hour and consisting of aerobic, resistance, and flexibility exercises. The protocol was divided into aerobic exercise and resistance training combined with aerobic exercise. The patients were evaluated with two assessments: one prior to their beginning the exercise program and other at the end of the four-month program. In both assessments the patients completed the Revised Piper Fatigue Scale and the six-minute walk test. The primary outcome of change over baseline and after 16 weeks in PFS-R score and six-minute walk test were compared using a two sample two-sided t-test for both groups. Alpha level was set at p < 0.05. Results: After 16 weeks, the patients who participated in the aerobic or the combined exercise program reported significantly higher levels of physical functioning (6-minute walking test, p = 0.0009 and p = 0.001, respectively) and significantly lower fatigue (PFS-R, p = 0.003 and p = 0.002, respectively) than at the beginning the exercise program. Conclusion: The results of patients who underwent aerobic or aerobic + anaerobic exercise showed statistically significant improvement of physical performance and of fatigue. Data from this study corroborates with the literature showing that exercise programs with aerobic or resistance exercises are an effective strategy for the treatment of fatigue. The results of this study confirm that physical exercise could be useful in rehabilitation of cancer survivors, especially for fatigued patients.
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