Immunobiologic therapy is indicated for severe forms of psoriasis, resistant to
conventional therapy. There is growing concern about their safety profile and
possible association with cancer development. This article documents two cases of
renal cell cancer during treatment with biologic therapy, reviewing what is described
in the literature . The risk of solid tumors as a complication of using TNF-alpha
inhibitors is controversial. No conclusion can be drawn from the data in the
literature, however, we believe that special attention should be given to those with
known risk factors for a specific neoplasm.
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