O estudo objetivou descrever o desempenho funcional e a presença de doenças crônicas em 164 idosos residentes em Instituições de Longa Permanência, em Recife-PE, Brasil. Foram aplicados um questionário sociodemográfico, a Medida de Independência Funcional, a escala de Lawton e o Mini-mental. A análise de variância foi utilizada para avaliar as diferenças dos resultados. Os idosos eram predominantemente solteiros, mulheres, com baixa escolaridade. Entre os motivos de admissão destacaram-se: abandono, saúde frágil e vivência em rua. Encontrou-se alto percentual de doenças crônicas; 70% dos idosos eram dependentes para as atividades de vida diária, e todos eram dependentes para as atividades instrumentais. A demência foi o que mais afetou a funcionalidade, seguida das doenças osteoarticulares e do transtorno mental. Entre as atividades comprometidas destacaram-se o uso de escadas e o controle de esfíncteres, sendo a alimentação a de melhor desempenho. Verificou-se que os idosos institucionalizados apresentaram comprometimento funcional e situação de vulnerabilidade social.
Background Ustekinumab (UST), an anti-interleukin-12/23 antibody, has successfully been introduced in the treatment of IBD, mainly in patients failing anti-TNF-agents. The STOCUSTE study includes IBD patients treated with UST at four teaching hospitals in Stockholm to provide long-term follow-up data. Here, we report the outcome in Crohn’s disease over the first 12 months. Methods This retrospective study includes patients diagnosed with Crohn’s disease and treated with UST who were followed until withdrawal of treatment for any reason, or until end of study, July 31, 2021. Disease activity (Harvey-Bradshaw Index (HBI); Physician Global Assessment (PGA), laboratory parameters and drug persistence were assessed. The primary outcome was remission (HBI ≤4; PGA = 0) and response (decrease HBI ≥3; PGA ≥1 from baseline) at 3 and 12 months, respectively. Results 120 patients, 61 women (51%), with a median age of 27 (IQR 27) at start of UST were included. All patients had luminal disease and 19 (16%) also fistulizing disease. 109 (91%) had failed ≥1 and 59 (49%) ≥2 anti-TNF drugs. In addition, 50 patients (42%) failed vedolizumab. At inclusion, 106 (88%) had active disease; 40 (33%) were on corticosteroid treatment and 22 (18%) on thiopurines. The persistence on UST was high, 93% at 3 months and 56% at 12 months. Of patients on UST at 3 months, 38% were in remission, and, at 12 months, 53%. An additional 26% were in response at 12 months. Of the 40 patients initially on corticosteroids, 17 (43%) and 28 (70%) had stopped steroids at 3 and 12 months, respectively. The median faecal calprotectin level declined from 272 (90–1763) at baseline to 75 (49–99) µg/g at 3 months (p<0.01). There was a slight decrease in CRP over 12 months, from 3 (2–12) to 1 (1–2) mg/l, together with increases in haemoglobin and serum albumin (n.s). Withdrawal from treatment during the first 12 months was 44% (53/120), mainly due to persisting disease activity. Four patients were withdrawn due to adverse events, three needed bowel surgery, two had malignancy and one patient suffered from systemic infection. Conclusion In this group of difficult-to-treat patients with Crohn’s disease, UST was shown to be effective in the majority, with high drug persistence at 12 months in combination with a favorable safety profile.
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