Objective:It is well known that reciprocal and Robertsonian translocations carriers have increased risks of producing aneuploidies gametes associated with the meiotic multivalent, which ones abort spontaneously or end with the birth of an abnormal child. Method: We present our preliminary experience with 8 (eight) cases of PGD of balanced translocations with trophectoderm biopsy , genetic study by aCGH and deffered transfer. Seven cases were reciprocal translocations and only one was a Robertsonian translocation. From reciprocal translocations twenty two blastocysts were biopsied and ten from Robertsonian translocations. Results due to malsegrerelated to the meiotic quadrivalent. In the Robert-lanced by malsegregation of the meiotic trivalent and adjacent type 2 segregation and malsegregation 3:1, which imply important chromosomal unbalance. Out of the 8 (eight) performed cycles, only 4 were transferred with a normal aCGH blastocyst. Three of them achieved the pregnancy. Conclusion: Taking into account the results achieved with biopsy in day 3 and fresh transfer, it seems that the results in day 5 and deferred transfer are much better. Probably the biopsy performed in an embryo that reach the maximum stage of development in vitro and the transfer in a cycle with an endometrium more physiologically prepared are the main reasons for the best results.
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