In a double-blind, double crossover experiment, 18 healthy young men received over 3-day periods either 100 mg atenolol, 80 mg propranolol, or placebo. The subjects underwent various motor and cognitive tests 18 h after each last dose had been taken. Propranolol significantly increased variability of a choice reaction-time task. Scores on various subjective rating scales showed that propranolol had a larger mood elevating effect than atenolol. Heart rate and blood pressure were significantly reduced 24h after atenolol medication; these effects were absent or reduced after propranolol had been given.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.