We report a 53-year-old woman who presented with multiple painful red cutaneous papules that had been growing slowly for 13 years. Histopathology showed typical features of neuroma. Biological, morphological and genetic investigations were negative and excluded the diagnosis of multiple endocrine neoplasia type 2b. After reviewing the literature, we concluded that our patient has an extremely unusual acquired disease, which must be considered as a distinct entity in the spectrum of cutaneous neurological disorders.

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by Ramos et al., 10 a large number of genetic, epigenetic, regulatory and environmental factors are involved in the development of SLE. Thus PTEN deficiency may be just one of many contributory factors in a subset of cases. However, the current evidence does seem to support the idea that decreased expression of PTEN, by mutations or by miRNA, may play a role in SLE pathogenesis. Further investigations into the cause of increased miR-17-92 cluster expression in patients with SLE, as well as characterization of the frequency of positive serum lupus markers in patients with PHTS, are warranted.