Background and purpose: Low arterial pressure and systemic vascular resistance in patients with acute on chronic liver failure (AOCLF) may be caused by an overload of albuminbound endogenous vasodilatory substances that not are cleared by the failing liver. We aimed to determine if removal of albumin-bound as well as water-soluble substances from the blood stream by treatment with MARS improves arterial pressure and systemic vascular resistance in patients with AOCLF.
Background and purpose: In patients with acute on chronic liver failure (AOCLF), hepatic encephalopathy (HE) may be caused by albumin-bound as well as water-soluble neuroinhibitory factors that are not cleared by the failing liver. In this study we aimed to determine if removal of such "neurotoxins" by MARS treatment would increase cerebral perfusion in patients with AOCLF and alleviate HE.
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