Background: This cross-sectional study assessed Female Sexual Function Index (FSFI) scores in premenopausal women with breast cancer diagnosis. We aimed to determine variables that are associated with sexual dysfunction and if these thematic is being addressed by healthcare professionals.Methods: The FSFI questionnaire was administered to 199 premenopausal women 6 months after completing breast cancer initial treatment (surgery, radiation therapy or chemotherapy). A demographic questionnaire was administered. Scores were compared between sexually active women sub-groups. Questions, regarding FSFI acceptability and to find out if healthcare professionals are addressing these thematic were included.Results: The study included 199 women. Thirty-three were excluded from analysis because they declared no sexual activity in the 4 weeks before the survey. Ninety-seven women met the FSFI cutoff score for a sexual dysfunction. FSFI Scores were significantly lower in women treated with radiation therapy and in women treated with radical mastectomy and lumpectomy when compared with mastectomy with immediate reconstruction. One hundred and thirty-eight women were never or rarely questioned about their sexual health even though 71.2% reported feeling comfortable about sharing this problematic with doctors. Both sexually active and non-active women provided positive feedback about the FSFI.Conclusion: FSFI scores were compatible with sexual dysfunction in more than half of the sexually active women. Women treated with radiation therapy, radical mastectomy and lumpectomy had significant lower FSFI scores. With desirable acceptability, the FSFI is suitable for screening for sexual dysfunction in premenopausal women with
33m, low expression/negative 66m (logrank test p¼0.0041), Figure1: p16(+) in 10(41.6%), survival 36.2m, p16(-) survival 66.8m, p16/PD-L1(-) survival 66.8m, p16/PD-L1(+) survival 36.2m. Conclusion: SCC with PD-L1 TPS50%, p16(+), smokers with high/tumor/burden had lower survival rates. Immunotherapy against programmed cell death (PD-1) is a promising alternative impacting survival in advanced/metastatic NSCLC.
Introduction: Thymic clear cell carcinoma is the most uncommon subtype of thymic carcinoma, with 20 cases reported worldwide. Case Description: We present the case of a 61-year-old female with dyspnoea and chest pain for 2 days. Computed tomography (CT) angiography showed pulmonary thromboembolism and the existence of mediastinal and bilateral hilar lymphadenopathy, the largest infracarinal with an inferior axis of 25 mm, and also, micronodules on the left pulmonary parenchyma. The patient was admitted for aetiological assessment and underwent anticoagulant therapy. After a month, she had an ischaemic stroke, the sequelae of which proved to be fatal. The autopsy showed a mass in the superior-anterior mediastinum, with dimensions of 11×8×6 cm, corresponding to a thymus signet ring cell primary carcinoma. The immunohistochemistry study revealed that this mass was positive for AE1/AE3, CK5/6 and CK7. Conclusion: The clinical, morphological and immunophenotypic diversity of this tumour makes its diagnosis a difficult multidisciplinary challenge, which requires a high level of clinical knowledge and accurate imaging and histological investigation.
Background: Breast cancer (BC) survivors report adverse sexual effects such as disrupted sexual function (SF) and sexual distress. Despite its high prevalence, sexual dysfunction (SD) is not effectively screened for or treated.
We included 388 patients. Median age: 72 years; range (28-98). 65% were males. ECOG 0-2: 68%; 3-4: 32%. Most frequent primary tumors were lung (23%), upper gastrointestinal (19%) and colorectal cancer (16%). Most common symptoms leading to hospital admission were deterioration of the general condition (51%), dyspnoea (12%) and infection (10%). On multivariate analysis, attention by HPCU was the only significant feature to reduce the number of emergency care unit visits and hospital admissions (OR 5.67, p¼<.001 and OR 8.62, p¼<.001, respectively). Data shown in table . Conclusions: Patients receiving HPCU assistance have lower number of emergency room visits and hospital admissions which leads to decreases the public health spending, and improvement in quality of life. Thus, providing adequate resources to HPCU should be a priority for the management of oncologic patients at the end of life.
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