A family with tricho-rhino-phalangeal syndrome in 3 female members is reported. The pedigree is consistent with an autosomal-dominant mode of inheritance.
30 male Syrian hamsters were X-ray irradiated on 1 ear with 500 rad (Dermopan 2; setting 3; tissue half value thickness, 7.5 mm). 30 other animals were treated locally on one ear with an emulsion containing 0.15% 8-methoxypsoralen and then with UV A (10 treatments in 23 days; total UV A dose, 5.0 J/cm2). The other ear served as control. An in vivo double-labelling autoradiography with 3H- and 14C-thymidine was carried out on half of the animals of each group. The other half was administered 3H-thymidine and the number of labelled cells still in contact with the basal lamina of the sebaceous gland after 6 days was determined. The effects of X-ray irradiation and photochemotherapy are identical. Cell proliferation in the sebaceous gland was reduced, the length of the S phase was shortened, and the number of marked cells still in contact with the basal lamina after 6 days was decreased.
Lange Zeit galt die Höhensonnenbehandlung als eine Indikation zur Therapie der Akne. Untersuchungen von Mills und Kligman haben gezeigt, daß bei Heranziehung objektiver Kriterien keine Besserung der Akne gefunden werden konnte. Nachdem die Photochemotherapie insbesondere bei der Behandlung der Psoriasis und der Mykosis fungoides Eingang in die dermatologische Therapie gefunden hatte, wurde von Tronnier und anderen auch die Akne als Indikation für eine PUVA‐Therapie angegeben. Umgekehrt fanden Hofman et al. bei Untersuchungen PUVA‐behandelter Patienten vereinzelt als Nebenwirkung der Therapie eine akneiforme Follikulitis. Durch mikrobiologische und zellkinetische Untersuchungen unserer Arbeitsgruppe wurde versucht, den Wirkeffekt einer standardisierten PUVA‐Therapie zu analysieren.
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