The elasticity in diurnal serum BDNF variation is associated with favourable treatment response to PSD in patients suffering from MDD. Therefore, a normalized BDNF serum profile which oscillates in a circadian fashion seems to precede, rather than follow a favourable treatment outcome in depressed patients. Furthermore the fast increase of BDNF is comparable to effects seen with ketamine infusion.

Attempted suicide produces substantial direct medical costs, which are only a part of the financial burden. Prevention targeting mood disorders, the elderly and the use of hard methods may be most cost-effective. Further research should aim at identifying additional indirect costs and the cost-effectiveness of prevention measures.

This study offers the first published representative data of an entire Swiss county. Established sociodemographic and clinical risk factors for suicide attempts were reproduced. The identification of risk factors contributes to developing local targeted prevention strategies, for example education of risk groups and caregivers, and pharmacolegal consequences for package sizes. Gender- and age-specific prevention and aftercare programmes are indicated.

Objective: Good and sufficient sleep is crucial for a good quality of life. We investigated the associations between sleep patterns, work, and strain among students of hospitality and tourism. Methods: 92 students completed psychological and sleep-related questionnaires, and a sleep/work log for one week. Results: Sleeping hours were inversely correlated with working hours. Decreased sleep quality was associated with increased scores of strain, depression and anxiety. Participants with increased working hours were 3.2 times more likely to report heightened insomnia scores than those with lower weekly working hours. Working on weekends was associated with increased strain with family life and peers. Conclusions: In hospitality and tourism, the employees' 'personal costs' for a 24/7 service may be underestimated; unfavourable work schedules are linked with decreased sleep quality, symptoms of depression, anxiety, and with social problems.

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