Abstract. 643 cases of salivary gland tumors constitute two series of histological sections that were studied from hospitals and dental schools in Southeast Scotland and Southern Ontario. The Scottish series represented epithelial tumors of the parotid and intra‐oral salivary glands, but the Canadian series also included tumors of the submandibular and sublingual glands. Classification was based on that recommended by the World Health Organisation (Thackray 1972). While direct statistical comparisons between the two series are not appropriate, the differences between them suggest that malignant tumors are more common in Canada. The Scottish series contains the largest proportion of benign salivary tumors so far imported. In the Scottish series, 88.7 % of parotid tumors were benign compared with 51.9% of the Canadian series. In the Canadian series from the submandibular glands, 21.2 % only were benign. Of the intra‐oral salivary tumors, 62.2 % from the Scottish series were benign compared with only 34.7 % from the Canadian series.
SUMMARY
Assays for human growth hormone (HGH) were carried out on 89 acromegalic patients, 81 of whom were studied before any treatment had been given. Serial studies were undertaken, generally at 6-monthly intervals, with the same test procedure, using a 50 g oral glucose tolerance test (GTT) and identical assay conditions over a period of 8 years. Twenty-three patients were assessed at intervals during periods of up to 4 years whilst they remained untreated. The general picture was one of unchanging HGH levels.
Ten patients were studied before and after external irradiation. HGH levels showed a slow continuing fall for as long as 4 years and thereafter they stabilized at one-third of pretreatment values. HGH levels in 12 patients treated with radioactive implants showed an immediate fall to one-third, and thereafter a further slow decline to one-tenth of pretreatment levels. The response in eight patients treated by surgical removal of pituitary tissue and subsequent radiotherapy varied considerably.
No patient, treated or untreated, showed evidence of partial suppression of HGH secretion during the GTT although three patients consistently responded to glucose with paradoxical hypersecretion.
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