(+)‐Physostigmine and (+)‐physovenine have been synthesized. The anti‐acetylcholinesterase activities of these two bases, which have been investigated in vitro using erythrocyte acetylcholinesterase, have been found to be much lower than the corresponding activities of the alkaloids (‐)‐physostigmine and (‐)‐physovenine. Possible reasons for these activity differences are discussed.
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