In Fabry disease, reduced TDI velocity seems to be the initial sign of cardiac involvement that occurs before the development of cardiac hypertrophy. ERT with agalsidase alfa delays the onset of cardiac involvement and should be considered at an earlier stage of the disease, even in the absence of left ventricular hypertrophy.
Summary:Comparison was made of the aetiology and methods of diagnosis in two series of patients meeting the classic criteria ofpyrexia ofunknown origin during 1968-1981 and during 1982-1989 seen in
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