IntroductionLong-term survivorship of total hip arthroplasty is strictly related to the bone-host interaction, where bone remodeling is the main factor [1]. The evaluation of bone mass surrounding the implant is the most reliable method, starting from the common observation that bone reacts to stable and well functioning implants with bone apposition according to Wolff's law, while bone resorption is the typical response to an unstable and mal-loading implant [2][3][4].In the last ten years, dual energy X-ray absorptiometry (DEXA) has become more popular among investigators of bone mineral density (BMD) around femoral stems, making it possible to quantify the bone filling, the space between bone and stem (interface bone growth), and the dynamic process of reabsorption, apposition and transformation which involves the whole bone segment containing the implant (bone remodeling) [5][6][7].The first experience with DEXA started in the early 1990s, with observations regarding application and limits and then moving to clinical trials [8,9]. The new concept of minimally invasive surgery in the field of total hip arthroplasty means, in our opinion, not only a small incision, but also a physiological load transfer from the stem to the bone with a conservative stem design, like CFP prosthetic stem (Waldemar Link, Hamburg, Germany).Abstract Periprosthetic bone remodeling, and its evaluation, are the keys of long-term survival of cementless total hip arthroplasty. Dual energy X-ray absorptiometry (DEXA) is the most accurate method to measure bone mineral density, evaluating the effects of bone-prosthesis interactions. We studied, 4 years after implantation, 10 patients who underwent total hip arthroplasty with the CFP prosthetic stem and TOP acetabular cup (Waldemar Link, Hamburg, Germany). Our results demonstrate minimal periprosthetic bone loss compared to that normally observed with conventional stems. A few cases exhibited an increase in BMD. We believe that primary stability, prosthetic design, preservation of natural neck anteversion and off-set, better function related to muscle lever arm, and physiological bone loading with natural stress distribution are the keys of this succesful mini-invasive total hip replacement system.