kinases and PI3-kinase revealed that TCR independent, CD28 mediated Th2 differentiation is critically dependent on IL-4 stimulation and the activation of the MAP kinases p38 and ERK1/2. Whereas CD28 signals directly activated IL-4 and p38 in memory T cells, ERK phosphorylation required indirect stimulation by IL-2.
ConclusionThe results indicate that generation of Th2 effectors requires coordinate signalling via the CD28 and IL-2 pathways. The mechanisms regulating Th2 cell differentiation might provide valuable tools for therapeutic modulation of chronic autoimmunity.
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