An immunogenetic study of the response to streptococcal carbohydrate antigen of the cell wail was carried out on members of 15 multiplex families each having more than one sib affected with rheumatic heart disease.
Replicating the association of single-nucleotide polymorphisms in the TNFAIP3, IL12B and IL23R genes with psoriasis vulgaris, in subjects from different ethnic backgrounds, underlines their importance in the pathogenesis of the disease. In contrast, the lack of any association between rs20541 (IL13) and psoriasis in our Egyptian cohort suggests the existence of important inter-ethnic genetic differences in psoriasis susceptibility.
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