Objective:To evaluate the predictive impact of chromosome 1p/19q deletions on the response and outcome of progressive low-grade gliomas (LGG) treated with up-front temozolomide (TMZ) chemotherapy. Methods: Adult These tumors share an invasive and malignant potential. Gross total surgical resection, whenever possible, is recommended. Radiotherapy is considered as a postoperative standard treatment for LGG, although the optimal timing of this treatment (i.e., immediate vs at progression) remains debatable. 3,4 We and others have recently provided some evidence based on small studies that temozolomide (TMZ), an oral alkylating agent, may represent an interesting alternative option as a primary treatment after surgery in diffuse LGG. [5][6][7] We have reported preliminary results suggesting that chromosome 1p deletion is correlated with radiographic response of LGG to TMZ and might represent a helpful molecular tumor marker for guiding therapeutic decision-making. 6 In the present study we report additional data from an extended series of patients with longer follow-up confirming the efficacy of TMZ in progressive LGG and the predictive value of 1p/19q loss both in terms of prognosis and chemosensitivity.From APHP, Service de

Acute febrile illnesses comprise the majority of the human disease burden in sub-Saharan Africa. We hypothesized that arboviruses comprised a considerable proportion of undiagnosed febrile illnesses in Guinea and sought to determine the frequency of arboviral disease in two hospitals there. Using a standard case definition, 47 suspected cases were detected in approximately 4 months. Immunoglobulin M antibody capture enzyme-linked immunosorbent assays and plaque-reduction neutralization assays revealed that 63% (30/47) of patients were infected with arboviruses, including 11 West Nile, 2 yellow fever, 1 dengue, 8 chikungunya, and 5 Tahyna infections. Except for yellow fever, these are the first reported cases of human disease from these viruses in Guinea and the first reported cases of symptomatic Tahyna infection in Africa. These results strongly suggest that arboviruses circulate and are common causes of disease in Guinea. Improving surveillance and laboratory capacity for arbovirus diagnoses will be integral to understanding the burden posed by these agents in the region.

Introduction: Dialytic high blood pressure (DHBP), although often ignored, is now recognized as a recurring and persistent phenomenon in a subgroup of hemodialysized patients. Its occurrence is associated with an increased risk of hospitalization and death. The objective of the study was to determine the prevalence of intradialytic hypertension and the factors associated with it. Methods: Study was cross-sectional, monocentric, descriptive and analytical over a three-month period from April 22 to July 22, 2019. Included were all patients 18 years of age or older, chronic hemodialysis for at least three months, with intra-dialytic high blood pressure. The blood pressure machine used for the majority of patients was an electronic "OMRON" blood pressure monitor. Epidemiological, clinical, para clinical and dialysis parameters were studied. The data were collected, captured and analyzed using IBM SPSS Statistics Version 20 software. The factors associated with intradialytic high blood pressure were searched using a univariate logistic regression model. The significance threshold for all statistical tests has been set at 5%. Results: Of our 131 patients, 53 had intradialytic hypertension, a frequency of 40.5%. The time of (DHBP) occurrence was more frequent at the 3rd and 2nd hour, 94.34% and 86.79%, respectively. The average age of patients was 45.51 years with extremes ranging from 19 to 70 years. The average Systolic Blood Pressure (SBP) before dialysis was 148 mm Hg −16.62 and the average Diastolic Blood Pressure (DBP) before dialysis was 88 mm Hg −12.50. Pre-dialysis Blood Pressure-140/90 mm Hg was noted in 18 cases, or 34.0%. The intradialytic average SBP was 164 mm Hg −17.25 with extremes of 121 to 202 mm Hg. The intradialytic average DBP was 92 mm Hg −12.

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Introduction: In Guinea, data on the acute kidney injury (AKI) of women in the obstetrical context is still limited. This study attempted to determine the prevalence and the clinical signs of obstetric AKI in Guinea. Patients and methods: The study population consisted of pregnant or postpartum women with AKI, whom we treated in this institute from August 2018 to January 2019. All had normal anterior renal function with serum creatinine clearance ≥ 120 μmol/L, and then suffered AKI. Patients characteristics were examined; maternal age, gestational weeks, AKI characteristics. Results: Of 2438 pregnant women admitted during the study period, 56 showed AKI. Antepartum and postpartum AKI accounted for approximately 80% and 17%, respectively. Regarding the maternal age, <25 years of age accounted for 54% (range: 17-40). Multiple gestations accounted for 34 (60.71%) of which functional AKI, organic AKI, and obstructive AKI accounted for 28/34, 2/34, and 4/34, respectively. Regarding the clinical manifestations, abdominal pain, tinnitus, visual disturbances, edema of the lower limb, and facial swelling accounted for 79%, 75%, 7%, 57%, and 54%, respectively. Conclusion: We here demonstrated peripartum AKI in Guinea, which findings may provide fundamental data to establish some strategy against this condition in this region.