expression (PFS [HR 2.3, P = .001] and OS [HR 1.9, P = .009]) and IPI (PFS [HR 1.7, P = .001] and OS [HR 1.8, P = .001]) were independent prognostic factors. This was also seen in the subgroup of intensively treated patients. In univariate analysis, similar trends were seen when only patients with primary DLBCL were included.
Conclusions:In this prospective cohort of DLBCL, high BMI-1 expression was a negative independent prognostic factor of both PFS and OS in univariate and multivariate analysis adjusting for IPI and COO. The prognostic effect was seen in all patients, including subgroups of intensively treated patients as well as patients with primary DLBCL (trends). High BMI-1 expression was related to non-GCB phenotype and transformed lymphoma (trends). Thus, BMI-1 expression is a possible novel negative prognostic biomarker in DLBCL and should be further investigated.
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