Background While computed tomography (CT) exams are the major cause of medical exposure to ionising radiation, there is increasing evidence that the potential radiation-induced risks must be documented. We investigated the impact of cellular models and individual factor on the deoxyribonucleic acid double-strand breaks (DSB) recognition and repair in human fibroblasts and mammary epithelial cells exposed to current chest CT scan conditions. Method Twelve human primary fibroblasts and four primary human mammary epithelial cell lines with different levels of radiosensitivity/susceptibility were exposed to a standard chest CT scan exam using adapted phantoms. Cells were exposed to a single helical irradiation (14.4 mGy) or to a topogram followed, after 1 min, by one single helical examination (1.1 mGy + 14.4 mGy). DSB signalling and repair was assessed through anti-γH2AX and anti-pATM immunofluorescence. Results Chest CT scan induced a significant number of γH2AX and pATM foci. The kinetics of both biomarkers were found strongly dependent on the individual factor. The topogram may also influence the biological response of radiosensitive/susceptible fibroblasts to irradiation. Altogether, our findings show that a chest CT scan exam may result in 2 to 3 times more unrepaired DSB in cells from radiosensitive/susceptible patients. Conclusions Both individual and tissue factors in the recognition and repair of DSB after current CT scan exams are important. Further investigations are needed to better define the radiosensitivity/susceptibility of individual humans.
(1) Background: The IVIscan is a commercially available scintillating fiber detector designed for quality assurance and in vivo dosimetry in computed tomography (CT). In this work, we investigated the performance of the IVIscan scintillator and associated method in a wide range of beam width from three CT manufacturers and compared it to a CT chamber designed for Computed Tomography Dose Index (CTDI) measurements. (2) Methods: We measured weighted CTDI (CTDIw) with each detector in accordance with the requirements of regulatory tests and international recommendations for the minimum, maximum and the most used beam width in clinic and investigated the accuracy of the IVIscan system based on the assessment of the CTDIw deviation from the CT chamber. We also investigated the IVIscan accuracy for the whole range of the CT scans kV. (3) Results: We found excellent agreement between the IVIscan scintillator and the CT chamber for the whole range of beam widths and kV, especially for wide beams used on recent technology of CT scans. (4) Conclusions: These findings highlight that the IVIscan scintillator is a relevant detector for CT radiation dose assessments, and the method associated with calculating the CTDIw saves a significant amount of time and effort when performing tests, especially with regard to new CT technologies.
Monte Carlo methods have become widespread in the field of radiation protection and in particular in medical physics where the use of voxelized volumes for the reconstruction of dosimetric quantities is increasing. Changing the resolution of a dose map can be useful to compare dosimetric results coming from voxelized volumes with different resolutions, or to reduce computation time. This can be done by superimposing a dosel grid with a different resolution than that of the voxelized volume. In this case, each dosel will cover several voxels, leading the Monte Carlo code to calculate the dose in heterogeneous volumes. Two algorithms are available in GATE to perform these calculations, the Volume-Weighting (V-W) and the Mass-Weighting (M-W) algorithms, the latter being the subject of this work. In a general way, the M-W algorithm tends to reconstruct a higher dose than that the V-W one. In dosels involving heavy and lightweight materials (air-skin, bone-tissue), the M-W reconstructed dose is better estimated than the V-W one (up to 10% better at the air-skin interface). Moreover, the statistical uncertainty of the M-W dose can be up to 80% lower than the V-W one at air-skin interfaces. These results show that the M-W algorithm is more suitable for radiological protection applications and must be preferentially used in GATE for dose calculations in heterogeneous volumes.
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