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ExtractGH is necessary for the replication of subcutaneous adipose ceFls. It has also been shown that successful treatment of This study was undertaken to evaluate adipose cell size amd hygopjtuitary patients with WGH reduces skinfold number and subcutaneous fat and blosd lipids composition in the first months-Thereaftm, skinfold thickness hypopituitary ~a t i e n t s before and during treatment with. inGzeaa progressiveky and mturns to pretreatment values human growth hormone (BGH). The investigations were which E e att*ed aftm 4-5 y a r s of t h e~a p y (1, 26, 27, 32, performed in 14 prepubertal children 6-11 11/12 y e a s of 33). age, with idiopathic hypopituitarism. Human growth h o m a n e B~~~~~~ madjficatiolts d adipocfles explain the was administered successfully to 6 of these 14 patients for at changes in skhfold tkcknem observed dun;ng treatment with least 1 year.HGH, this study was, under;t&en to emluate adipose cell size Before HGH treatment there was a significant reduction of and nmber and subcutme~pus fat and blood composiadipose tissue cell number according to chronologic age and t o ti,n ini h y g o p i t~t w y p8ieIrEts before and dm.g skeletal age. The average adipose cell size was significantky HGH. larger than normal. A significant correlation between subcutaneous adipose cell mean-weight and tricipital and subscapular skinfold thickness, similar to that observed in normal children, was observed. The distribution of fatty acids in the subcutaneous fat and in the blood lipid composition was normal.During the 1st and 2nd year of HGH treatment, the total number of adipose cells increased rapidly. There was also a highly significant reduction of the average adipose cell size after the 1st year. A significant reduction of the fatty acids unsaturated fraction was observed after the 1st year without further changes after the 2nd year of treatment. The blood lipid composition did not change significantly after either 1 or 2 years of HGH treatment. SpeculationThe striking increase in total number of adipose cells observed during HGH administration in hypopituitary patients tends to prove that the adipose tissue organogenesis is not limited to a finite period ending after the 1st year of life.The modifications in composition of adipose tissue triglycerides induced by long term treatment with HGH would mean that the several components of the fatty acid pool are differentially liberated.The importance of growth hormone (GH) for the multiplication of muscle, cartilage, or liver cells has been well established both in man and in animals (9). Brook (7) has shown that at the end of intrauterine growth and during the first year of life, MATERIALS AND METHOID& STJBJECTSThe investigations were performed int 14 prepubertal children, 10 boys and 4 girls, 6-1 7 11/12 years of age, with idiopathic hypopituitarism. Clinical data are su~nmarized in Table I. G r o u p I contains the hypopituitary subjects who have been treated subsequently with HGH, whereas group I1 consists of patients untreated SKI far. The standa...

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