Rodriguez et al. [1999] reported on a fetus with neonatal Hutchinson-Gilford progeria syndrome (HGPS) in a recent issue of this journal. We have been involved with a similar child with some manifestations in common with this fetus. We suggest that a diagnosis of neonatal HGPS is incorrect in both cases and, in fact, that HGPS does not manifest itself as a neonatal condition.Our patient, a girl, was born at 38 weeks of gestation to a healthy 32-year-old gravida 2 para 1 mother and a 33-year-old father. The parents were nonconsanguineous. The pregnancy was uneventful until the end of the third trimester when an ultrasound survey demonstrated oligohydramnios and intrauterine growth retardation (IUGR). At birth, length was 43.8 cm, weight 1,700 g, and OFC 28.5 cm. Physical examination (Fig. 1) showed a progeroid appearance, no subcutaneous fat, wrinkled and thin skin, large and multiple angiomas from the top of the skull to the base of the spine, prominent veins, and umbilical hernia. Facial anoma- Fig. 1. Picture of the child at birth. Note the progeroid appearance with absence of subcutaneous fat, wrinkled and thin skin, prominent veins, umbilical hernia, and facial anomalies (pseudohydrocephalic appearance of the skull, triangular face, sparse scalp hair, prominent eyeballs, sparse eyebrows and no eyelashes, small nose, apparently low-set and abnormal ears with small lobes, small mouth, and microretrognathia).