Lymphocytes from twenty-one (16-6%) of 126 men with non-obstructive azoospermia or severe oligospermia showed blastoid transformation in culture when exposed to normal semen homogenate, indicating their ability to produce antibodies against seminal antigen (s).In the diagnosis of aspermatogenesis of immunological origin, the blastoid transformation test is believed to have advantages over other tests which depend on the direct estimation of circulating antibodies against spermatozoa.There is evidence that testicular injury may be involved in the production of immunological aspermatogenesis in man.
Corticosteroids were used in the treatment of a group of eighteen non-obstructive azoospermic or severely oligospermic patients showing a positive lymphocyte blastoid transformation test in response to a seminal antigen. A control group of eleven similarly affected patients with negative blastoid transformation tests was given the same treatment. Response was noticed in nine of the positive test group (50%), and one patient's wife conceived. None of the control group showed any response.The value of this trial therapy is discussed. c
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