Objectives: Despite the growing use of intraoperative functional mapping in supratentorial low grade glioma (LGG) surgery, few studies have compared series of patients operated on without and with direct electrical stimulation (DES) by the same team. The present study compared the rate of LGG surgery performed in eloquent areas, the rate of postoperative sequelae, and the quality of resection during two consecutive periods in the same department-the first without and the second with the use of intraoperative electrophysiology. Methods: Between 1985 and 1996, 100 patients harbouring a supratentorial LGG underwent surgery with no functional mapping (S1). Between 1996 and 2003, 122 patients were operated on in the same department for a supratentorial LGG using intraoperative cortico-subcortical DES (S2). Results: Comparison between the two series showed that 35% of LGGs were operated on in eloquent areas in S1 versus 62% in S2 (p,0.0001), with 17% severe permanent deficits in S1 versus 6.5% in S2 (p,0.019). On postoperative MRI, 37% of resections were subtotal and 6% total in S1 versus 50.8% and 25.4%, respectively, in S2 (p,0.001). In both groups, survival was significantly related to the quality of resection. Conclusions:The results of the present study allow, for the first time, quantification of the contribution of intraoperative DES in LGG resection. Indeed, the use of this method leads to the extension of indications of LGG surgery within eloquent areas; to a decrease in the risk of sequelae; and to improvement of the quality of tumour resection, with an impact on survival. In the past decade, a growing number of authors have investigated the use of intraoperative mapping with direct electrical stimulations (DES) during tumour surgery near or within eloquent areas. It has been claimed that this method allows minimising postoperative permanent deficit while maximising the quality of resection, particularly in infiltrative tumours such as low grade gliomas (LGGs). 1-21However, few comparative studies of two series of patients operated on without and with DES by the same team are available in the literature. [22][23][24] Due to the parallel development of neurofunctional imaging techniques, the real role of intraoperative DES is still matter of debate, since this has not been statistically proven. 25In the present study, we compared three variables, the rate of LGG surgery performed in eloquent areas, the rate of postoperative sequelae, and quality of tumour resection, during two consecutive periods in the same department, the first without the use of intraoperative electrophysiology and the second with DES (1996DES ( -2003. The aim of our work was not to study the impact of surgery on the natural history of LGG, but to try to quantify the exact contribution of the DES in surgical resection of supratentorialLGGs.
The authors found that AVFs with retrograde cortical venous drainage present a high risk of early rebleeding (35% within 2 weeks after the first hemorrhage), with graver consequences than the first hemorrhage. They therefore advocate complete and early treatment in all cases of AVF with cortical venous drainage revealed by an ICH.
Indications of surgical treatment for lesions in the central nervous system depend on the risk of a definitive neurological deficit, related to the benefit of resection. Detection of eloquent areas is then necessary because of major individual variability. Neuro-imaging functional techniques are in development and are beginning to be efficient for cortical sensorymotor mapping, but still lack sensitivity and specificity for language mapping, and remain unable to give real-time data during surgery and to perform sub-cortical mapping. The more precise and reliable method of functional mapping is represented by the intra-operative direct electrical stimulations (DES), which allow identification and preservation of essential pathways for motricity, sensibility and language, at each level of the central nervous system (cortico-subcortical). We report our experience of DES in the surgery of tumours and vascular malformations located in supra-tentorial brain eloquent areas, with a consecutive series of 60 patients operated on under general or local anaesthesia, from November 1996 until May 1999 in our department at La Salpêtrière Hospital. Presenting symptoms in the 60 subjects (39 males, 21 females, mean age: 45 years) were seizures in 37 cases with normal clinical examination, and mild neurological deficit in 29 cases. MRI showed 60 supra-tentorial brain lesions: 30 precentral, 12 postcentral, 14 perisylvian in the dominant hemisphere, 4 deep-seated. All subjects underwent surgical resection using DES, with supratentorial cortico-subcortical mapping under general anaesthesia for motor areas detection in 43 cases and under local anaesthesia for sensori-motor and/or language tasks in 17 cases. The final histological diagnosis was 44 gliomas (31 low-grade and 13 high-grade), 9 metastasis, 3 cavernomas, 4 arteriovenous malformations (AVM). Resection was total or subtotal in 52 cases (87%) and partial in 8 cases (13%). 29 patients had no post-operative deficit, while the other 31 patients were impaired post-operatively, with in all cases, except 3, a complete recovery delayed for 15 days to 3 months (overall morbidity: 5%). The median follow up was 14 months. Intra-operative direct electrical stimulations of the central nervous system constitute a reliable, precise and safe method, allowing the realization of a functional mapping useful for all operations of lesions located in eloquent areas. This technique allows a minimization of definitive post-operative neurological deficit, and concurrently an improvement in the quality of resection.
Although intracranial cavernomas are known to cause haemorrhage, data concerning the frequency, severity and delay of recurrent bleedings are controversial. We report a series of 6 patients with histologically proven cavernoma, presenting with early clinical signs and radiological proof of rebleeding, that is occurring in the first month after initial overt haemorrhage. These 6 cases have been selected from a series of 142 patients seen between 1980 and 1995 in our department with cavernous angiomas or so-called AOVMs, of whom 93 presented with clinical symptoms of haemorrhage (34 patients presented symptoms of one or more rebleeding, but only 6 had radiological proof). All patients suffered neurological worsening due to the rebleeding, with an increase of the size of the haematoma on the CT scan. Five MRIs were performed at the acute stage: 3 showed evidence of cavernoma (60%). All patients underwent surgery at the acute stage of the rebleeding, with 5 improvements and 1 stabilization. A cavernous angioma was found in 5 cases at first surgery, but a further operation was necessary in the last patient to find and remove the cavernoma, after a second rebleeding following the first intervention. Our series reveals a high frequency of rebleeding after a first intracranial haemorrhage from a cavernous angioma, and highlights the precocity of such rebleedings. Therefore, we advocate early aggressive surgical management: in cases of cavernoma revealed by a first clinical overt haemorrhage, when there is strong radiological suspicion at the acute stage; and in all cases of rebleeding, even without radiological evidence of malformation, in the absence of vascular risk factors. Surgical indication must be discussed in particular cases of cavernomas of the brain stem when neither the haematoma nor the cavernoma reach the surface, and in deep supratentorial cavernomas, when the neurological status is good, because of the therapeutic risk.
A classification of arteriovenous malformations (AVM) is proposed, which is based on a retrospective analysis of the records and results of radical operation in 57 patients between 1983 and 1990. It represents the new developments and more recent technical facilities which influence operability of supratentorial AVMs. Predictability of outcome has been settled upon three groups of factors: anatomical, haemodynamical, and clinical. Anatomical factors are localisation and sectorisation of AVM, determination, caliber and straightening of feeding arteries. Haemodynamical factors are volume of AVM and vascular autoregulation, circulatory velocity of red blood cells in the main arteries of the neck and brain tissue cellular steal. Clinical factors are age, previous rupture of AVM, associated diseases and malformations of vital organs. Each of these factor groups has been divided into parameters to which a code number from 0 to 5 according to the severity of the considered parameter has been attributed. When a contraindication for radical surgery was clearly obvious, as, for example, an AVM with extension to the upper brain stem, number 10 was given. This grading has been done by a team of four persons (3 neurosurgeons including the senior author, and one biophysicist). By adding up all code numbers an Operability Score for a given patient is defined by the number of points, with a minimum of 3 and a maximum of 69. In cases with a score higher than 30 surgery is not advisable. A score between 21 and 30 indicates that always several staged operations are required, whilst only some of the patients with a score between 11 and 20 may require two stage operative treatment. The AVM in patients with a score under 10 can always be radically excised in a single stage operation. We have been able to demonstrate that the Operability Score allows a reliable prediction of outcome, thus giving indications and contraindications for surgery, and also for the surgical strategy. Moreover, we have explained why surgery had been refused in 9 additional cases during the same period. The causes of 8 fatalities out of 57 surgical cases are analyzed. These 57 cases represent a systematically explored series of the senior author; his experience is based upon 295 personal AVM cases (1958-1990).
This paper concerns the historical developments and technical properties of haemostatic devices used in neurosurgery with the exception of coagulation. Therefore there are described haemostatic clips designed for the scalp, clips used on arteries and veins, a clamp for the reduction of the carotid diameter in the neck, and a clamp for closing the venous dural sinuses. Special reference will be made regarding non ferro magnetic Phynox clips by Aesculap.
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