SummaryFrom a collection of viruses isolated over a period of years from clinical material and not identifiable by routine procedures, three were selected for this investigation. All three isolates were recovered in 1958 from cases of aseptic meningitis. Cross neutralization tests revealed that they were antigenically indistinguishable. One of these, 275/58, isolated from the cerebrospinM fluid of a 3 year old child, was chosen for detailed study. The general characteristics of this virus were found to be compatible with those of enteroviruses as specified by the Committee on Enteroviruses. Human origin of this virus was established by neutralization tests with patient's serum, pooled human gamma globulin and human sera submitted during enterovirus seasons from cases suspected to have virus infections. The 275/58 virus was not neutralized either by intersecting pools or individuM antisera prepared against all known enteroviruses, nor by WHO enterovirus reference antisera. Conversely, antiserum to 275/58 virus failed to neutralize poliovirus types 1--3, echovirus types 1--33, Coxsackie virus B 1--B 6 and Coxsackie virus A 9. The virus was found to be non-pathogenic for infant mice.It is suggested that these three isolates represent a new enterovirus serotype, possibly belonging to the echovirus group.
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