Introduction: To achieve success in endodontic treatment, the root canal system should be as sealed as possible with suitable material such as gutta-percha and sealer. Objective: This study compare the apical leakage of roots obturated with GuttaCore™, lateral condensation, and continuous wave obturation through a computerized fluid-transport system. Material and methods: Fiftytwo freshly extracted upper molars were used. The disto-buccal roots were cut and standardized to 10 mm long. The root canals were prepared at working length with WaveOne primary reciprocating files. The specimens were randomly divided and filled by one of the following obturation techniques: GuttaCore™, lateral condensation or continuous wave obturation, using SILCO sealer. The positive controls were left unfilled and the negative controls were totally coated with cyanoacrylate and three layers of nail polish. The roots were stored in relative humidity for 72 h at 37°C, allowing the sealer to set. After this period, the roots were connected to a computerized fluidtransport system, and the apical leakage was analyzed. Results: The results were expressed in µL.cmH2O-1.min-1 x10-4 1.36 atm. The data were statistically analyzed using one-way ANOVA and Tukey´s tests. The specimens of the positive control group showed extreme amounts of apical leakage. There was no leakage in the negative
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