The manuscript describes the doubly decarboxylative Giese reaction between N-(acyloxy)phthalimides and coumarin-3-carboxylic acids or chromone-3-carboxylic acids.
In the manuscript, reductive and decarboxylative azaarylation
of
coumarin-3-carboxylic acids is described. It utilizes the photocatalytic
activation of (cyano)azaarenes in the presence of
fac
-Ir(ppy)
3
as a photocatalyst. The methodology is versatile
and provides access to biologically relevant 4-substituted-chroman-2-ones.
Visible light, photoredox catalyst, base, anhydrous solvent, and inert
atmosphere constitute key parameters for the success of the described
strategy. The developed methodology involves a wide range of coumarin-3-carboxylic
acids as well as (cyano)azaarenes.
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