Indonesia is a large archipelagic country and it is a tropical country with a huge variety of plants. Borneo as one of five major islands has tropical rainforest with a high level of plants diversities in the world. Traditional treatment by medicinal plants is still used by the people in Pelangsian village. The purpose of this study was to find out how the way the people in Pelangsian village use the traditional medicines, also about the type and the benefits of medical plants there, and which parts of the plants that used to be the traditional medicines. This research uses the descriptive method with a qualitative approach, data collecting is done by making an observation and interviews. Sampling in this research used purposive sampling technique in order to determine key informant with criteria that have been determined by the researcher and snowball sampling that determines the next informant who has already recommended by the key informant before. The result of the research was there are 52 species of medicinal plants that have been determined, the leaves, trunks, peels, fruit, seeds, roots, woods, rhizomes, are the parts of the plants that usually used by the people there and the way to use those herbs is boiled, stacked, rubbed and consumed directly.
This study aims to obtain the profile of Thin-Layer Chromatography (TLC) and Ultraviolet-Visible (UV-Vis) spectrophotometry from ethanol extract of akar kuning stems (Arcangelisia flava) from Central Kalimantan. The TLC method is used with the orientation phase of the combination of polar-non-polar solvents resulting from orientation, while ethanol is used as the solvent for UV-Vis spectrophotometers. TLC results showed the formation of 3 stains on a combination of polar solvents chloroform : methanol : water while in a non-polar solvent combination n-hexane : ethyl acetate did not show any stains. Comparison of retention factor (Rf) values show the best combination of polar solvents to separate stains at a ratio of 5 : 2 : 1, respectively. Separation in 2-dimensional TLC with polar solvents showed a similar pattern with 1-dimensional separation in the form of 3 stains. UV-Vis spectrophotometer results showed 4 main peaks with wavelength 227.2; 267.4; 345.2; and 425.3 nm, respectively. The profile of the peak formed is very similar to that shown by berberine, one of the main metabolites of akar kuning. TLC and UV-Vis spectrophotometers profiles obtained are expected to support further research using akar kuning stems, especially those from Central Kalimantan.
Kidney disease includes various diseases and disorders affecting the kidney function. If not treated immediately then there will be kidney failure. Patients with Chronic Kidney Disease (CKD) require hemodialysis due to impaired endocrine, metabolic, electrolyte and acid-base functions. Hemodialysis is a substitute for kidney function to remove the rest of the metabolism. These hemodialysis actions can affect the quality of life of patients. The purpose of this study was to determine the quality of life of CKG patients undergoing hemodialysis therapy in dr. Doris Sylvanus Hospital Palangka Raya. This research uses the univariate quantitative method with a descriptive approach. Data were collected using a questionnaire adapted from the World Health Organization Quality of Life (WHOQoL)-BREF containing 26 items of questions covering four dimensions: physical, psychological, environmental and social. The sample used in this study as many as 30 people. Based on the assessment of the quality of life in this study showed that physical and psychological dimensions including in moderate quality of life, and environmental and social dimensions including a good quality of life.
Percutaneous Coronary Intervention (PCI) adalah salah satu perawatan untuk penyakit arteri koroner selain penatalaksanaan obat dan tindakan Coronary Artery Bypass Graft (CABG). PCI secara signifikan mengurangi gejala PJK, mengurangi angka kematian, dan meningkatkan kualitas hidup, tetapi beberapa pasien dapat mengalami kecemasan setelah PCI karena beberapa faktor. Tujuan dari penelitian ini adalah untuk mengidentifikasi kecemasan dan faktor-faktor terkait demografi. Penelitian ini merupakan penelitian deskriptif dengan teknik total sampling. Total sampel adalah 80 responden. Data dikumpulkan menggunakan Depression, Anxiety, and Stress Scale (DASS), kemudian dianalisis dengan analisis univariat. Hasil penelitian menunjukkan bahwa 78,8% responden adalah laki-laki, 52,5% berusia 56-65 tahun, 52,5% bekerja, 93,8% menikah, 42,5% berpendidikan sekolah menengah, 71,2% berpenghasilan 1,1-3 juta, 83,8% tidak pernah menjalani PCI dan 72,5% responden berada dalam tingkat kecemasan sedang. Oleh karena itu diperlukan tindakan yang tepat untuk mengurangi kecemasan pasien yang menjalani PCI seperti berbagi pengalaman, pendekatan perilaku kognitif,, teknik napas lambat, distraksi, hipnosis, serta adanya tim psikiatri yang terlibat dalam tim perawatan pasien yang menjalani PCI
Objectives: Akar kuning (Arcangelisia flava) was known to have various pharmacological activities including as antibacterial. Several Gram-positive and Gram-negative bacteria show response to akar kuning secondary metabolites, although the type of metabolites that inhibit the growth of each type of bacteria not yet known. This study aims to obtain the prediction of metabolites from akar kuning with the greatest antibacterial potential against various types of antibacterial receptors.Methods: Molecular docking was performed using Autodock Vina 1.1.2 on several secondary metabolites of akar kuning against active site of several antibacterial receptors that were known for many antibiotics including as cell wall, protein, nucleic acid synthesis inhibitors, and antimetabolites. The main parameter used was the free energy of binding as affinity marker.Results: The docking results show that among 11 metabolites studied, 6-hydroxyfibraurin, berberine, and fibleucin provided the lowest free energy of binding between 11 antibacterial receptors compared with natural substrates or inhibitors from each receptor. Interesting results show by berberine as inhibitor of protein synthesis with possibility of allosteric site discovery. Berberine also shows more than 75% similarity with natural substrate of cell wall inhibition receptor, indicating possible similar type of interaction.Conclusion: Overall, it seems that for the selected secondary metabolites of akar kuning, the main mechanism of action was the inhibition of protein and cell wall synthesis, which was shown by berberine.
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