The aim of this research work was to identify the Boundary-Line Approach (B-LA) macro-nutrient optimum concentrations linked to maximum yield and sufficiency ranges at 90% maximum yield per 1-year-old fructification cladode for Opuntia ficus-indica (L.) Miller variety "Rojo Pelón". Four years' (2012-2015) data of yield per fructification cladode and macro-nutrient concentration [nitrogen (N), phosphorus (P), potassium (K), calcium (Ca), or magnesium (Mg)] were used to elaborate bivariate scatter diagrams (n = 228). Selection from 9 to 11 points was performed to estimate quadratic functions as boundary-lines in each bivariate scatter diagram. The vertices allowed estimation of the optimum macro-nutrient concentrations:
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