The use of new cosmetic ingredients, unlike traditional hydrogels, represents a differentiated platform for preparation of stable semisolid formulations containing polymeric nanocapsules, presenting physicochemical properties suitable for topical use.

The aim of this study was to prepare and characterize permethrin-loaded lipid core nanocapsules (P-LNC) in order to produce a long last insect repellent spray formulation for clothes. P-LNC were prepared by self-assembling in aqueous solution showing a mean diameter of 201 +/- 4 nm with a monomodal distribution, a permethrin content of 4.6 +/- 0.1 mg/mL and zeta potential of--16.7 +/- 4 mV. P-LNC (0.46%), as well as the commercial product (0.46%) and the hydroalcoholic solution (0.50%) of permethrin were separately sprayed onto cotton or polyester, followed by successive washes of the fabric. The results showed that the fabrics treated with P-LNC are more resistant than other solutions in terms of remaining permethrin content. After twenty washes, the cotton treated with P-LNC, presented a concentration of 566 +/- 27 mg/M2 of impregnated permethrin, while for the treatment with the substance hydroalcoholic solution and with the commercial product the concentrations values were of 340 +/- 7 mg/M2 and 224 +/- 74 mg/M2, respectively. When the test was performed using polyester, this fiber was less adhesive than cotton, resulting in a final concentration of permethrin (after 20 washes) of 81 +/- 10 mg/m2 for P-LNC suspension, 94 +/- 8 mg/M2 for the substance hydroalcoolic solution and 22 +/- 3 mg/M2 for the commercial product. After impregnating cotton with the formulations and submitting to a temperature of 200 degrees C, the P-LNC also demonstrated higher adherence compared to the other formulations (407 +/- 67 mg/m2 for P-LNC, 236 +/- 72 mg/m2 for the substance hydroalcoholic solution and 158 +/- 62 mg/m2 for commercial product). These results showed that the repellent spray composed of P-LNC developed in this work is a promising and innovative product for the individual protection against insects, useful for impregnation onto cotton garments.

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Ⅺ Lipid nanoparticles have been developed for application of active substances to the skin, both for pharmaceutical and cosmetic uses. In the present work, we proposed the first application of a nonrefined natural biodegradable and biocompatible lipid-Cupuaçu seed butter ( Theobroma grandiflorum)-for the preparation of lipid nanoparticles, which are called theospheres. Theospheres were prepared by two different methods, emulsification-solvent evaporation and high pressure homogenization technique, using Cupuaçu butter at different concentrations. Theospheres prepared by both methods showed size in the nanometrical range (around 200 nm) and narrow particle size distribution (0.2). Theosphere suspensions were stable for 30 days, excepting the systems containing 15 and 20% of butter prepared by emulsification-solvent evaporation method. Multiple light scattering analyses showed that physical instability was avoided by increasing the number of homogenization cycles during preparation in the systems prepared by high pressure homogenization. The DSC and X-ray analysis showed that the preparation method influenced the cristallinity of the lipid in the theospheres. The results showed that Cupuaçu butter is an alternative and promising compound for nanoparticle formulation, especially if it is used in concentrations up to 10%, irrespective to the preparation method.