Purpose:To compare the use of new cyanoacrylate surgical adhesive associated with macroporous tapes in cutaneous synthesis.Methods:Male Wistar rats with a longitudinal incision of 4cm were used on the back, divided into four groups: GI used octyl-cyanoacrylate (Dermabond®), GII used N-2-butylcyanoacrylate, GIII used octyl-cyanoacrylate and macroporous tape and GIV used N-2-butyl cyanoacrylate and macroporous tape. On the fourteenth day, the rats were submitted to euthanasia, were divided in two parts, and a layer of skin subcutaneous tissue through an area of operative healing was removed. One part was submitted to the study of rupture strength with the use of tensiometer, and in the other part histological examination was performed.Results:No force test was similar between groups I and II, being different from groups III and IV (P <0.001), which were identical to each other (P> 0.05). The units were compared among the studied groups, and they were different with the use of macroporous tapes (P> 0.05).Conclusions:The purpose of macroporous tapes is associated with CA adhesives in cutaneous tissues that provide more resistant scars. The use of a combination of macroporous tapes leads to complete re-epithelialization, without provoking foreign body reaction, has hemostatic properties and does not cause an absorptive reaction.
Colon cancer is a growing health problem in Brazil. According to data from the World Health Organization (WHO), colon cancer is among the top ten causes of mortality and morbidity in the world. Besides, the disease has a significant economic impact on the Brazilian public health system. Over the past five years, there has been an increased interest in use, isolation, characterization and determination of the biological actions of compounds such as broccoli. Experimental studies with genetically modified (GMOs) rats, mice, and rats using Sulforaphane have demonstrated their ability to prevent, delay and reverse pre-neoplastic lesions, improved survival, as well as acting on neoplastic cells with therapeutic action. Sulforaphane through activation of Nrf2 increases the activity of phase II enzymes such as glutathione S transferase (GST), which is involved in the elimination of xenobiotic compounds. Aberrant crypts are induced, in Wistar rats and mice, by genotoxic and non-genotoxic chemical compounds. Colon carcinogenesis is generally induced in rats and mice by two substances, 1,2-dimethylhydrazine (DMH) and azoxymethane (AOM). Azoxymethane is often used concerning DMH because it is more potent and requires few reactions for its activation. It is possible to conclude that Sulforaphane, through its various biological actions, presents efficiency in the prevention of colon cancer and significant potential for use in future experimental studies with genetically modified rats, mice, and rats.
Economic and social development has essential repercussions on the health of populations, as it alters the morbidity and mortality profile and favors the increase in exposures and risks to human health, especially the risk of cancer. Cancer is considered a significant public health problem worldwide, and remains with high incidence rates, being considered a complex disease, with multifactorial causes. The permanent incidence rates of prostate cancer prove to be one of the most prevalent, considered the second most common cancer in men worldwide, and a leading cause of deaths from chronic noncommunicable diseases. Among the different types of cancer, prostate cancer has been the subject of great scientific interest. In this context, animal models are valuable for studying cancer-related aspects, the use of animal models has the potential to increase our understanding of carcinogenesis, tumor biology, and the impact of specific molecular events on tumor biology. Animal models with specific human cancer characteristics can be used to test cancer prevention and treatment strategies. In this review, we aim to show how the use of animal models as an essential tool in the study of the molecular mechanisms of carcinogenesis.
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