The dextran-bound antirheumatic agent, Naproxen [ ( + )-2-(6-methoxy-2-naphtyl)propionic acid] (3) was synthesized by linking the 2-aminoethyl ester of Naproxen to the oxydized dextran via an alkylamine bond. The hydrolytic stabilities of modified dextrans were examined viscometrically. The drug release from polymeric prodrug samples containing 68 -172 mg of Naproxen per g product was followed at 37 "C by automatic titration at pH 8,4. The first order kinetic constant of hydrolysis, k l , was determined to be 2,46( +0,4) . s -'. Acute toxicity tests showed no toxic effect on CFLP mice administered intraperitoneally 300 mg/kg of dextran-bound Naproxen.
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