Societal crises and stressful events are associated with an upsurge of conspiracy beliefs that may help people to tackle feelings of lack of control. In our study ( N = 783), we examined whether people with higher feelings of anxiety and lack of control early in the COVID‐19 pandemic endorse more conspiracy theories. Our results show that a higher perception of risk of COVID‐19 and lower trust in institutions' response to the pandemic were related to feelings of anxiety and lack of control. Feeling the lack of control, but not anxiety, independently predicted COVID‐19 conspiracy theory endorsement. Importantly, COVID‐19 conspiracy beliefs were strongly correlated with generic conspiracy and pseudoscientific beliefs, which were likewise associated with the feeling of lack of control and lower trust in institutions. The results highlight that considering people's emotional responses to the COVID‐19 pandemic is crucial for our understanding of the spread of conspiracy and pseudoscientific beliefs.

We examined whether scientific reasoning is associated with health-related beliefs and behaviors over and above general analytic thinking ability in the general public ( N = 783, aged 18–84). Health-related beliefs included: anti-vaccination attitudes, COVID-19 conspiracy beliefs, and generic health-related epistemically suspect beliefs. Scientific reasoning correlated with generic pseudoscientific and health-related conspiracy beliefs and COVID-19 conspiracy beliefs. Crucially, scientific reasoning was a stronger independent predictor of unfounded beliefs (including anti-vaccination attitudes) than general analytic thinking was; however, it had a more modest role in health-related behaviors.

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Febrile neutropenia (FN) remains a potentially life-threatening complication of anticancer chemotherapy. Bacterial translocation via intestinal mucosa is a significant mechanism of FN development. Competitive inhibition of bowel colonization by pathogenic microorganisms by lactic acid bacteria could be a useful prevention of FN. The aim of the study was the prevention of FN by probiotic strain Enterococcus faecium M-74 enriched with selenium in leukemic patients. Fourteen (six males/eight females) patients with myelogenous leukemia treated by induction or consolidation chemotherapy were included in the study. Patients received prophylaxis with E. faecium M-74 during one cycle of chemotherapy. The daily dose was 36 x 10(9) CFU tid. Prophylaxis started between day -2 and day +2 of chemotherapy and continued until the absolute neutrophile count (ANC) was >1,000/microl. All patients experienced febrile neutropenia. During 231 days of severe neutropenia, 30 febrile episodes occurred. No any febrile episode or infection provoked by the strain tested was noticed. Tolerance of therapy was excellent without significant adverse effects. Our results demonstrate the safety of the probiotic strain E. faecium M-74 enriched with selenium in leukemic patients with severe neutropenia. However, its administration was not effective in the prevention of febrile neutropenia, but this does not preclude the protective effect of other probiotic strains.

GREEN (NCT01905943) is a non-randomized, open-label phase IIIb study investigating obinutuzumab alone or plus chemotherapy in chronic lymphocytic leukemia (CLL). We report a preplanned subgroup analysis of 158 previously untreated CLL patients receiving obinutuzumab–bendamustine (G-B). Patients received six 28-day cycles (C) of G-B: obinutuzumab day (D)1/D2 of C1 (25 mg D1/975 mg D2), 1000 mg D8 and D15 of C1, and D1 of C2–6; and bendamustine 70/90 mg/m2 D1 and D2 of C1–6. The primary endpoint was safety/tolerability. Grade ≥3 adverse events (AEs) occurred in 82.3% of patients, including neutropenia (49.4%), thrombocytopenia (12.0%) and febrile neutropenia (10.8%). Serious AEs included neutropenia (12.7%), febrile neutropenia (9.5%) and pneumonia (7.6%). Rates of grade ≥3 infections and infusion-related reactions were 20.3% and 17.1%, respectively. Due to tumor lysis syndrome (TLS; 8.2%), including two associated fatalities (one in another study cohort), additional risk-minimization measures were implemented. Overall response rate was 81.0%. After 32.8 months’ median observation time, 2-year progression-free survival was 81.8%. Minimal residual disease was undetectable in 59.5% (94/158) and 27.8% (44/158) of patients for blood and bone marrow, respectively. Frontline G-B appears to have manageable toxicity with clinical activity in CLL. Careful TLS risk assessment, pretreatment and monitoring is required.

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Threatening events (hurricanes, disease outbreaks, famines) are associated with an upsurge of conspiracy beliefs that provide people with simple explanations to tackle the feelings of anxiety and lack of control. In our study (N = 783), conducted shortly after the first cases of COVID-19 were identified in our country, we examined whether people with higher anxiety and lack of control concerning the pandemic adopt more conspiracy beliefs about the origin, spread and potential cure of the new coronavirus. We also tested whether the rise of coronavirus-specific conspiracy beliefs is associated with the endorsement of generic epistemically suspect (i.e. paranormal, conspiracy, and pseudoscientific) beliefs as well. Our results show that higher perception of risk and lower trust in institutions concerning the COVID-19 pandemic were related to the feelings of anxiety and lack of control which in turn predicted an increase in coronavirus-specific conspiracy beliefs. Importantly, these beliefs were further related to the higher endorsement of generic paranormal, conspiracy, and pseudoscientific beliefs. The results show how threatening events, such as the current pandemic, lead to a rise in various epistemically suspect beliefs by increasing people’s feelings of anxiety and lack of control.

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