The direct alkynylation of the electrophilic gem-difluorinated propene derivative (I) is achieved via a simple allylic substitution reaction. In the case of the 1,1-difluorinated propene derivative (IV), which has two electrophilic sites, the regioisomers (VI) are obtained. -(HWANG, J. H.; HONG, Y. Y.; YANG, E. J.; JEONG*, I. H.; Bull. Korean Chem. Soc. 32 (2011) 2, 405-406, http://dx.doi.org/10.5012/bkcs.2011.32.2.405 ; Dep. Chem., Yonsei Univ., Wonju 220-710, S. Korea; Eng.) -H. Hoennerscheid 24-082
Regioselective Addition Reactions of 3-Phenylsulfonyl-2-trifluoromethyl--1,3-butadiene with Nucleophiles. -The regioselective addition of various nucleophiles to title compound (I) is studied. A stereoselective formation of pyrrolidine derivative (IV) is observed when amine addition product (IIId) is heated in 2,2,2-trifluoroethanol. That surprising cyclization seems to be pretty sensitive to the reaction conditions. -(YANG, E. J.; JEON, S. L.; JEONG*, I. H.; J. Fluorine Chem. 143 (2012) 198-203, http://dx.
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