Adipogenesis is the process of adipocyte differentiation which increases lipid accumulation and ROS production. Many studies revealed that obesity is caused by excessive lipid accumulation and it leads metabolic diseases. Also, ROS production by oxidative stress induced insulin resistance which accompanies obesity and is a risk factor of type 2 diabetes. Ginsenoside Rg1 is one of the major components in panaxa ginseng, as a class of steroid glycosides, and triterpene saponins. Our result showed that Rg1 decreased lipid accumulation, C/EBPα, PPARγ, aP2 mRNA expression, C/EBPα, PPARγ protein expression and ROS production in a dose‐dependent manner. In addition, protein expression of early aipogenic factor C/EBPβ which induces C/EBPα, PPARγ was reduced during early adipogenesis. Our data suggests that Ginsenoside Rg1 inhibits lipid accumulation and ROS generation during early adipocyte differentiation. Depend on these data, we are planning to investigate anti‐oxidative factors.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.