A new pyridothieno[3,2-b]indole and pyridothieno[3,2-c]cinnoline derivatives are designed and prepared form corresponding 3-amino-2-arylthieno[2,3-b]pyridines.
By molecular docking method novel potential inhibitors of DNA gyrase B are identified among the thieno[2,3-b]pyridine derivatives. In addition, some of prepared pyridothienoindoles exhibit in vivo antidote activity against the herbicide 2,4-D.
For the final print and online versions, the compound numbers in refs. 12 and 14 have been corrected to match the schemes and text. In addition, reagent 3 is now mentioned in the text (in the paragraph discussing Scheme 1) and in the experimental section (ref. 12).
Synthesis of a Novel Tetracyclic Pyrido[3',2':4,5]thieno[3,2-b]indole System. -(KANISHCHEVA, E. A.; VASILIN*, V. K.; KASIMOVA, D. R.; STROGANOVA, T. A.; KRAPIVIN, G. D.; Chem. Heterocycl.
Thermolysis of 3-Azido-N-phenylthieno[2,3-b]pyridine-2-carboxamides. -Thermal decomposition of the title azides (II) is accompanied by an intramolecular cyclization furnishing novel fused benzodiazepinone derivatives (III). -(KANISHCHEVA, E. A.; VASILIN*, V. K.; STROGANOVA, T. A.; KRAPIVIN, G. D.; Chem. Heterocycl.
Various title compounds (V) and (IX) are obtained by thermolysis of alkyl(aryl) 3‐azidothieno[2,3‐b]pyridine‐2‐carboxylates containing an aryl or heteroaryl substituent at position C‐4 of the thienopyridine core (IV) and (VIII).
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