In the current study, we describe a clinical case of the right upper lobectomy at Situs inversus totalis (SIT). Our report is the first described case in the domestic literature of SIT in a patient with multiple primary metachronous cancer, when a patient with SIT had primary lung cancer and successful surgical treatment. SIT is a complex and extremely rare clinical situation for the surgeon. In all such patients, it is advisable to use all available methods of imaging and diagnosis in the preoperative period, to clarify the anatomical structure of the vascular bed and bronchial tree.
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