We perform here enhanced sampling simulations of N-terminally acetylated human α-synuclein, an intrinsically disordered protein involved in Parkinson's disease. The calculations, consistent with experiments, suggest that the post-translational modification leads to the formation of a transient amphipathic α-helix. The latter, absent in the non-physiological form, alters protein dynamics at the N-terminal and intramolecular interactions.
Quantitative MS-based proteomics enabled to distinguish metabolic differences of triple negative breast cancer cells and corresponding chemoresistant and cancer stem cells (CSC). This puts mitochondria in a spotlight for cancer therapy and places bactericidal antibiotics;particularly linezolid-as effective agents for eliminating CSC and resistant cells.
Graphical Abstract
Highlights• OMICS distinguish cancer cells from resistant or cancer stem cells.• Bactericidal antibiotics and mitochondria.• Linezolid and anticancer therapy.
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