We have conducted a pilot validation study for the NeuroTouch tumor resection scenario and demonstrated for the first time, face, content and construct validity of a VR neurosurgical simulation exercise. Future full-scale studies will be conducted in noncompetitive settings and incorporate expert participants.
Bismuth triflate catalyzes the Mannich-type reaction of a variety of in situ generated aldimines using aldehydes, anilines, and silyl enol ethers in a three-component reaction. The reaction proceeds rapidly and affords the corresponding protected beta-amino ketones in high yields (up to 94%).
Rhodium(II)-catalyzed reactions of vinyldiazoacetates with dihydronaphthalenes were systematically studied. These substrates underwent cyclopropanantion and/or the combined C—H activation/Cope rearrangement in good overall yield and with good diastereo- and enantiocontrol. The selectivity of these reactions was profoundly influenced by the nature of the chiral catalyst, the vinyldiazoacetate and the dihydronaphthalene. The best combinations for achieving the highest selectivity in the cyclopropanation and the combined C—H activation/Cope rearrangement of 1,2-dihydronaphthalenes are methyl 2-diazopent-3-enoate (2a)/Rh2(S-DOSP)4 and methyl 3-(tert-butyldimethylsilyloxy)-2-diazopent-3-enoate (2b)/Rh2(S-PTAD)4. These combinations are very effective at enantiodivergent reactions of 1-methyl-1,2-dihydronaphthalenes.
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