Many articles have appeared within the past five years showing that sulphonamide therapy has effected a considerable reduction in the number of fatalities due to cerebrospinal fever. These reports, most of which are based on groups of less than a hundred cases, are not in agreement on certain matters, such as the sulphonamide compound of choice, its proper dosage, and the value of serum as an adjuvant to chemotherapy. Such differences in experience with cerebrospinal fever are to be expected, since the disease is notoriously variable in severity and in its effect on persons of different ages. In the present communication an attempt is made to obtain information on some of the points in question by means of an analysis of a large number of case reports.
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