Glaucoma, a complex heterogenous disease, is the leading cause for optic nerve-related blindness worldwide. Primary open angle glaucoma (POAG) is the most common subset and by the year 2020 it is estimated that approximately 60 million people will be affected. MYOC, OPTN, CYP1B1 and WDR36 are the important candidate genes. Nearly 4% of the glaucoma patients have mutation in any one of these genes. Mutation in any of these genes causes disease either directly or indirectly and the severity of the disease varies according to position of the genes. We have compiled all the related mutations and SNPs in the above genes and developed a database, to help access statistical and clinical information of particular mutation. This database is available online at http:bicmku.in:8081/glaucoma The database, constructed using SQL, contains data pertaining to the SNPs and mutation information involved in the above genes and relevant study data.AvailabilityThe database is available for free at http:bicmku.in:8081/glaucoma
A growing number of diseases seem to be associated with protein aggregation and each disease has several proteins involved in it. To obtain a better understanding of the diseases, the proteins involved in them and their primary interaction partners were collected and clustered. A tool is developed to aid in clustering these proteins and all their primary interactors. The tool is used to cluster proteins involved in Primary Open Angle Glaucoma and their primary interactors. A cluster was selected for analysis based on the availability of experimental analysis in literature. The localization of the proteins in the chosen cluster was collected. On analyzing, four of the proteins in the cluster was found to be associated with heparin binding. Primary open angle glaucoma is known to be associated with loss of retinal vasculature. The tool has helped in finding a cluster of protein interactions with more experimental data. Also it has helped in finding out the 4 proteins associated with the disease that are involved in heparin binding from 10500 proteins. This would not have been possible to do manually. Further studying the role of these four proteins based on heparin binding and loss of vasculature in primary open angle glaucoma would give a better understanding of the disease and the molecular mechanism involved in it.
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