4,14-Diazaheptadecanedialdehyde (2b), the presumed cytoactive metabolite of the novel experimental antitumor agent iV,N'-bis(3-aminopropyl)nonane-1,9-diamine (lb), was synthesized as its dihydrochloride salt and evaluated for in vivo tumor growth inhibition. The same synthetic sequence was also used to prepare 4,9-diazadodecanedialdehyde (2a), the presumed metabolite of the ubiquitous polyamine spermine (la). The bisaldehyde products were characterized by microchemical analysis and ir and nmr spectral data and by conversion to their bis-2,4-dinitrophenylhydrazone derivatives. Studies with 2a and 2b established that they did not undergo spontaneous decomposition to acrolein under a variety of experimental conditions, including those normally employed in cell culture technique..V,./V'-Bis(3-aminopropyl)nonane-1,9-diamine (lb)2 is an experimental antitumor agent of novel chemical structure.
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