The purpose of this cross-sectional study was to investigate the effect of different forms of periodontal diseases on Oral Health-Related Quality of Life (OHRQoL). Fifty-two patients with Aggressive Periodontitis (AP) or Chronic Periodontitis (CP) were included: nine patients with Localized Aggressive Periodontitis (LAP), thirty-three patients with Generalized Aggressive Periodontitis (GAP) and ten patients with Generalized Chronic Periodontitis (GCP). Oral Health Impact Profile questionnaires (OHIP-14) were distributed after a clinical examination that measured the following periodontal parameters: tooth loss, bleeding on probing (BoP), probing depth (PD), gingival recession (REC) and clinical attachment level (CAL). The global OHIP-14 score means were 10.6 for LAP, 16.5 for GAP, and 17.5 for GCP. A statistically significant difference (p < 0.01) was observed between the LAP group and the other two groups. There was significantly less bleeding and recession in the LAP group than in the patients with the generalized forms of periodontitis. LAP, GAP and GCP have an impact on patient quality of life when measured using the OHIP-14. Patients with GAP and GCP had poorer OHRQoL than LAP patients.

Given the evidences that IgG response in AP patients correlated with bacterial infection level in GAP, but not in LAP, and that LAP patients lack a response to Tf, despite harbouring this species, our data suggest a difference in host immune defence between these two forms of aggressive periodontitis.

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Objective To evaluate the effect of the periodontal treatment on Aggregatibacter actinomycetemcomitans JP2 clone, and the IgG serum levels against its outer membrane protein (Omp29) and A. actinomycetemcomitans serotypes in aggressive periodontitis (AgP). Subjects and Methods Seventeen patients with generalized (GAgP), 10 with localized (LAgP), and 10 healthy controls were included. AgP participants were submitted to periodontal treatment—scaling and root planing plus antibiotics (SRP+A). Periodontal parameters, for example, probing depth (PD) and clinical attachment loss (CAL), were evaluated at baseline and at 1‐year. Serum IgG against Omp29 and serotypes a, b, and c were determined by ELISA. The levels of A. actinomycetemcomitans JP2 clone were determined in subgingival biofilm samples by qPCR. Results Periodontal treatment resulted in significant reductions of PD, CAL, and IgG levels against Omp29, serotypes b, and c. After therapy, IgG levels against A. actinomycetemcomitans serotypes, as well as the levels of the JP2 clone in AgP, became similar to controls. The reduction in JP2 clone count was correlated with a reduction of PD and IgG response against Omp29. Conclusion Scaling and root planing plus antibiotics decreased IgG levels response against Omp29 and A. actinomycetemcomitans serotypes involved in the disease (b and c), while the serum response increased against tne commensal serotype (a), similar to what occurs in periodontally healthy individuals.

O objetivo deste estudo transversal foi investigar o efeito de diferentes formas de doenças periodontais na qualidade de vida relacionada à saúde bucal (OHRQoL). Foram incluídos 52 pacientes com Periodontite Agressiva (AP) ou Periodontite Crônica (PC): nove pacientes com Periodontite Agressiva Localizada (LAP), trinta e três pacientes com Periodontite Agressiva Generalizada (GAP) e dez pacientes com Periodontite Crônica Generalizada (GCP) . Os questionários de Perfil de Impacto na Saúde Oral (OHIP-14) foram distribuídos após um exame clínico que mediu os seguintes parâmetros periodontais: perda dentária, sangramento na sondagem (BoP), profundidade da sondagem (DP), recessão gengival (REC) e nível de inserção clínica (CAL) ) As médias globais da pontuação do OHIP-14 foram 10,6 para o LAP, 16,5 para o GAP e 17,5 para o GCP. Diferença estatisticamente significante (p <0. 01) foi observado entre o grupo LAP e os outros dois grupos. Houve significativamente menos sangramento e recessão no grupo LAP do que nos pacientes com formas generalizadas de periodontite. LAP, GAP e GCP têm impacto na qualidade de vida dos pacientes quando medidos com o OHIP-14. Pacientes com GAP e GCP apresentaram pior QVRS que pacientes com LAP.