Background: Chronic obstructive pulmonary disease (COPD) is a common, preventable, and treatable disease characterized by persistent respiratory symptoms and airflow limitation that is due to airway and/or alveolar abnormalities, usually caused by significant exposure to noxious particles or gases. The chronic airflow limitation that characterizes COPD is caused by a mixture of small airway disease (e.g., obstructive bronchiolitis) and parenchymal destruction (emphysema) the relative contributions of which vary from person to person. Aim of work: The aim of the study was to determine the effect of systemic corticosteroids in patients with severe AECOPD admitted to intensive care unit (ICU) Receiving Ventilatory Support. Patients and methods: 100 patients with AECOPD leading to hypoxemia and respiratory acidosis with pH < 7.35 and PaCO2 > 45 mm of Hg admitted to the intensive care unit (ICU) who were receiving ventilator support (invasive or noninvasive mechanical ventilation). Results: It was noticed that steroid group had significantly lower duration of mechanical ventilation (4.67 ± 2.76 vs. 2.76 ± 1.11 days; P= 0.01), ICU stay (5.33 ± 2.87 vs. 7.89 ± 3.36 days; P= 0.04), hospital stay (11.65 ± 3.89 vs. 16.67 ± 4.44 days; P= 0.03). Conclusion:Corticosteroid therapy was associated with significantly lower duration of mechanical ventilation, ICU stay and hospital stay.
Background: Obesity-associated acanthosis nigricans is the most common type of acanthosis nigricans. Aim of wok: To detect leptin receptor expression in the skin lesion affected by obesityassociated acanthosis nigricans. Patients and methods: Twenty patients suffering from obesityassociated acanthosis nigricans were included in this prospective study. Complete history taking, thorough general examination and calculation of body mass index were done for all patients. Leptin receptor expression was investigated in skin lesion and perilesional skin by immunohistochemistry. Results:The mean age of the patients was 19.5 ±7.561 years and the mean duration of the disease was 8.6 ± 6.44 years. 14 patients were females and 6 patients were males. The mean BMI of the examined patients was (31.5 ± 4.4). The expression of leptin receptors was significantly higher in skin lesions than perilesional skin of the patients. Conclusion: leptin receptor expression was significantly higher in skin lesions affected by obesityassociated AN.
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