Vitiligo is a depigmenting skin disease that shows a global prevalence of 0.5%-2%, with rates varying across populations. 1 The stability of vitiligo is crucial in planning the treatment regimen and especially important for selecting patients eligible for surgery.However, the exact definition of vitiligo stability is controversial, with many difficulties in patient examination to confirm the stability of the lesions. 2 Vitiligo Disease Activity Score (VIDA) is a simple six-point scoring system used to evaluate vitiligo activity and stability in relation to time. The patient's own opinion is the base of the VIDA score. 3 The clinical criteria used to detect vitiligo stability include lack of progression of old lesions and absence of new lesions over the past 2 years, absence of recent Koebner phenomenon, and repigmentation of vitiligo lesions by medical treatment. 4 Moreover, poorly defined borders denote active vitiligo, while well-defined borders are found in stable disease, with these findings correlating with
Aims: The present study aimed to evaluate anti-diabetic properties of AgNPs/chitosan/ascorbic acid nanocomposites (Ag-NCs) in streptozotocin-induced diabetic rats. Main methods: Eighteen male Wistar albino rats were divided into three main groups (6 rats/group); control, diabetic and Ag-NCs groups. Control group: after a single dose of citrate buffer (0.1 mol/l, i.p), the rats orally received 1 ml distilled water daily for four weeks. The diabetic model was induced by a single dose of streptozotocin (60 mg/kg, i.p) for type 1diabetes. Diabetic groups were treated orally with and Ag-NCs (0.25mg/Kg body weight) daily for four weeks. Key findings: AgNPs/chitosan/ascorbic acid nanocomposite group showed a reduction in the concentrations of glucose, NO, MDA, creatinine, urea and uric acid. At the same time, it appeared a general increase in insulin, CAT, and SOD activities and GSH concentration. The histopathological investigation illustrated a clear improvement in renal architecture. Significance: The suggested mechanism of action for Ag-NCs in decreasing diabetic nephropathy includes two pathways; the hypoglycemic activity and the antioxidant role of Ag-NCs
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