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Management• Fifty-nine patients with onset of moderate to severe unimproving paralysis of less than 24 hours' duration were randomized into treatment (Dextran 40) and control groups, managed similarly except for the dextran. A strict effort to study a uniform cerebral process by rejecting patients with hypertension, insulin-dependent diabetes, potential emboli, and pulmonary or renal disease resulted in a small sample. Most patients considered for the study had begun to improve before the initial examination. All patients had spinal tap prior to the decision to randomize. Results were evaluated independently by the three authors over a three-week interval and tabulated after three years. A greater percentage of dextran-treated patients improved with respect to consciousness and strength in upper and lower extremities, but showed less restoration of language than the untreated patients. The differences in the two groups were not significant. One of 30 patients given dextran may have had a reaction.

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NINE FIGURESThe dog has been a frequent subject f o r laboratory studies of the cerebral circulation. A detailed description of this circulation was lacking before the work of Ellenberger and Baum (1891) and Tandler (1899). Bouclcaert and Heymans ( ' 3 5 ) added some information as a result of dissections of portions of the cerebral circulation in the course of their physiologic studies. More recently, Jewel1 ('52) gave a detailed anatomic description of the blood vessels of the head of the dog, showing the numerous anastomoses between external and internal carotid systems already known to physiologists. I n the process of conducting experiments on the production of infarcts in the brains of dogs, we realized there was a significant lack of information on the radiologic anatomy of the cerebral blood vessels. Localization of affected vessels was uncertain when seen in roentgenograms of the skull, and this problem could not be solved by referring to the literature.To overcome this deficit, angiograms were done in the living animal. Dissections were then performed after injec-

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