This preliminary study investigated whether bupropion sustained release (SR) improved symptomatic fatigue, depression and quality of life in cancer patients and caregiver quality of life. The sample consisted of a prospective open case series of 21 cancer patients, with fatigue and with or without depression at moderate to severe levels, referred for psychiatric assessment from a tertiary care cancer centre. Both patient symptom ratings and caregiver ratings were measured before and after 4 weeks of treatment with the maximally tolerated dose of bupropion in the range of 100-300 mg per day. At trial completion, significant improvement was found for symptoms of fatigue and depression. Subjects were divided into two groups: depressed and non-depressed (based on a cut-off score of 17 on the Hamilton Depression Rating Scale). Both groups reported improvement for fatigue and depressive symptoms. Depressed subjects and their caregivers did not experience any change in quality of life, while the non-depressed subjects and their caregivers reported improvements. Results from this small group of patients suggest that bupropion may have potential as an effective pharmaceutical agent for treating cancer-related fatigue. A randomized, placebo-controlled trial with this medication is indicated.

BackgroundStudies evaluating the benefit of adding motivational interviewing (MI) to behavioral weight-loss programs (BWLPs) have yielded mixed findings.MethodsThe aims of this randomized controlled trial were to: (1) assess the efficacy of adding MI to a BWLP on weight loss and adherence among 135 individuals with overweight and obesity (77.8% female; mean BMI = 33.6 kg/m2) enrolled in a 12-week BWLP and (2) explore levels of importance, confidence, and readiness for change ratings.ResultsParticipants, who were randomized to receive two MI sessions or two attention control sessions, were assessed at baseline, the end of the BWLP, and 6 months post BWLP. Both groups decreased their weight from baseline to the end of the BWLP; however, there was no weight change in either group when measured between baseline and 6 months post BWLP. We observed no group differences in importance, confidence, and readiness for change after each session.ConclusionsWe highlight some important lessons learned from the present trial that can be applied to MI + BWLP research. Participants may not have benefited from MI because they were already highly motivated to change, which highlights the importance of pretreatment assessment. Findings also suggest that treatment monitoring may help to enhance MI + BWLP efficacy by guiding a stepped-care approach that identifies individuals for whom additional MI sessions are needed, and when. A focus on refining elements of treatment remains an important direction.Trial registrationClinicalTrials.gov, Identifier: NCT02649634. Retrospectively registered on 5 January 2016.Electronic supplementary materialThe online version of this article (doi:10.1186/s13063-017-2094-1) contains supplementary material, which is available to authorized users.

With an increased focus on multidisciplinary care, psychologists are being called to work within palliative care teams. Spirituality is often a salient issue for palliative individuals, and has significant implications with respect to psychological functioning. This paper discusses the incorporation of spirituality/religion into psychological end of life care, with a focus on the biopsychosocial-spiritual model of health, and the consideration of spirituality/religion as an aspect of cultural diversity. Discussion also surrounds the ethical integration of spirituality/religion into psychological assessment and treatment, as well as recommendations for clinical training. An overall theme of this article is that attending to the spiritual needs of palliative individuals is important to fulfill one's ethical responsibilities as a psychologist. Thus, seeking ways to ethically integrate these concepts into psychology training and practice remains an essential endeavour.

The level of information conveyed in study advertising does not impact reporting of eating disturbances among nonclinical samples, although there is evidence social desirability might.

In the complicated relationship between early 20th-century feminism and eugenics, Western Canada in general and the Province of Alberta in particular provide a unique case study on the history and practice of the sterilization of the "feeble-minded." While feminism strove to enable women to control their own reproductive capacities, eugenics attempted to exert control over the reproduction of certain segments of society. Ironically, these movements exerted a significant influence on one another during their respective inceptions and were inextricably linked for more than 50 years. This paper discusses how misunderstanding and panic surrounding mental illness served to unite feminism with the eugenics movement. Specifically, the paper explores how first-wave feminism adopted a maternal ideology that embraced the role of "guardians of the race." How these events unfolded within Western Canada and the role that prominent feminists and women's associations played are reconstructed. Ultimately, it is argued that understanding the role that the feminist movement played in the application of eugenics legislation requires consideration of the importance of maternal feminism in the changing relations between the sexes.