We have demonstrated a novel platform of quantum dots (QDs) core-shell conjugated graphene oxide (GO) biosensor for effective protein detection. The advantage in making core shell nanostructure allows preserving stable QDs, by improving quantum yield, and lowering the toxicity of the core. Both QDs and GO are efficient nanoparticle systems that can potentially be used for drug delivery, diagnosis, and biosensors scaffolds. However, our study indicates that the conjugation between these two nanoparticle systems makes their properties even more effective. The change in fluorescent intensity through fluorescence resonance energy transfer from quantum dots to GO produced a novel method for detection of the target and allows for the optimization of the recognition limit of Bovine serum albumin (BSA) due to efficient fluorescence resonance energy transfer as observed through time resolved relaxation spectroscopy. It is observed that the quenching of photoluminescence peak of QDs due to GO shell produced an applicable strategy and could be conveniently extended for detection of other biomolecules. We obtained significantly enhanced spectral signal through successful conjugation of GO with CdSe/CdS core shell, which can potentially be used for the detection of biomolecules with high sensitivity and selectivity. Our study underlines the efficiency of QD conjugated GO core shell in spectral detection of proteins even at very low concentration (0.25 mmol).
We demonstrate high performance chemical bath deposited CdS thin-film transistors (TFTs) using atomic layer deposited ZrO 2 based high-k gate dielectric material. Our unique way of isolation of the CdS-based TFTs devices yielded significantly low leakage current as well as remarkable lower operating voltages (<5V) which is four times smaller than the devices reported on CdS-based TFTs using SiO 2 gate dielectric. Upon thermal annealing the devices demonstrate even higher performance, including FE exceeding 4 ± 0.2 cm 2 V -1 S -1 , threshold voltage V T of 3.8V and I on-off of 10 4 to 10 5 , which hold much promise for applications in future electronic and optical devices.
Quantum dots (QDs) are a hot topic in optoelectronic device research, due to tailorable absorption and emission properties. Unfortunately, the conventional methods of QD synthesis are hazardous and time-consuming. In this work, we present an alternative method of fabricating cadmium selenide (CdSe) QDs (via rapid microwave synthesis). This novel fabrication method provides a quick and efficient way to synthesize QDs that are almost identical to those commercially available. We also demonstrate the tuning of QD sizes by varying time and temperature during the growth process. Optical spectroscopy was used to measure the emission profile of QDs of various sizes. With ease repeatability, tunability, and scalability, this QD synthesis method can be integrated into a wide range of applications and optoelectronic devices.
The presence of denatured proteins within a therapeutic drug product can create a series of serious adverse effects, such as mild irritation, immunogenicity, anaphylaxis, or instant death to a patient. The detection of protein degradation is complicated and expensive due to current methods associated with expensive instrumentation, reagents, and processing time. We have demonstrated here a platform for visual biosensing of denatured proteins that is fast, low cost, sensitive, and user friendly by exploiting the plasmonic properties of noble metal nanoparticles. In this study we have exposed artificially heat stressed ferritin and gold nanoparticles to 3-aminopropyl triethoxysilane, which degrades the protein by showing a systematic blue shift in the absorbance spectra of the gold nanoparticle/ferritin and aminosilane solution. This blue shift in absorbance produces a detectable visual color transition from a blue color to a purple hue. By studying the Raman spectroscopy of the gold nanoparticle/ferritin and aminosilane solution, the extent of ferritin degradation was quantified. The degradation of ferritin was again confirmed using dynamic light scattering and was attributed to the aggregation of the ferritin due to accelerated heat stress. We have successfully demonstrated a proof of concept for visually detecting ferritin from horse spleen that has experienced various levels of degradation, including due to heat stress.
We demonstrate a highly sensitive, surface-plasmon-enhanced Raman spectroscopy (SERS) biosensing platform, composed of multilayer core-shell nanostructure of a CdSe core and surrounding ZnO monolayers for effective protein detection. This innovative technique uses a thermal decomposition method in the microwave to produce a rapid, less toxic, and a more convenient procedure of synthesizing nanometer thick metal oxide shells to form a core-shell structure. The benefit of using a metal oxide shell includes mitigating the toxicity of the core, increasing biocompatibility, and minimizing the photochemical and chemical corrosion of the semiconducting nanocrystals. In this study, we have presented a simple one-pot protocol for the formation of CdSe/ZnO core-shell quantum dots (QDs) in the microwave. Our study indicated the optimization of the recognition limit of bovine serum albumin (BSA) through a spectral signal at a considerably low concentration (2.5 µM). This nanoparticle core-shell system can be used for many thin film applications in the biomedical, alternative energy, and environmental fields.
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