Pityriasis Rubra Pilaris (PRP) is an uncommon skin disorder characterized by follicular keratosis, palmoplantar keratoderma, and erythroderma. The traditional preferred treatment is oral retinoids, but over the last decade, biologic therapy with anti-TNF agents has been used with success. We report the case of a 51 year-old man with a clinical and histopathological diagnosis of PRP. He underwent therapy with adalimumab and showed clearance of skin lesions within the fourth week of treatment.
ABSTRACT:The occurrence and geographic distribution of marine mammal strandings along Todos Santos Bay, Baja California, Mexico, were investigated from 1998 to 2001. The study was carried out along 30km of coast, divided into rocky and sandy shores. During the study period we responded to calls from the public about dead stranded marine mammals (SMM), and from March 1999 to December 2001 the coast was also monitored (211km total effort). A total of 153 SMM (90 from notifications, 63 from beach monitoring) from nine different species were recorded: 76% (n=117) were California sea lions (Zalophus californianus), the most abundant pinniped on the western coast of the Baja California Peninsula. Adult males stranded more often than other age and sex classes (P<0.05). The highest frequency of California sea lion strandings was located on sandy beaches (P<0.05) because carcasses may be deposited and remain more easily there than on rocky beaches. The 1998 El Niño event influenced stranding frequencies; most SMM were recorded during that year. As to seasons of the year, most SMM were recorded during spring; this may indicate a higher abundance of marine mammals in the area during this part of the year. Probable human-induced injuries were observed in 17% (n=26) of all animals. Most of these were Z. californianus (n=24), probably due to their known interaction with fisheries; 70% were males. RESUMEN:Se investigó la distribución espacial y temporal de los varamientos de mamíferos marinos en la Bahía de Todos Santos, Baja California, México, de 1998 a 2001. El estudio se realizó a lo largo de 30km de costa, dividida en costa rocosa y arenosa. Durante el periodo del estudio se respondió a llamados de la población sobre mamíferos marinos varados (MMV), y desde marzo de 1999 a diciembre de 2001 se hicieron monitoreos de las playas (211km de esfuerzo total). Se registraron un total de 153 MMV (90 de avisos, 63 de monitoreos) pertenecientes a nueve especies diferentes: 76% (n=117) fueron lobos marinos de California (Zalophus californianus), el pinnípedo más abundante en la costa occidental de la península de Baja California. Los machos adultos se vararon con más frecuencia que otras clases de edad y sexo (P<0.05). La mayor frecuencia de los varamientos de lobo marino de California se ubicó en playas arenosas (P<0.05), probablemente porque los cadáveres se depositan y permanecen más fácilmente ahí que en playas rocosas. El evento de El Niño en 1998 influenció las frecuencias de los varamientos; la mayoría de los MMV se registraron durante ese año. En cuanto a estaciones del año, la mayoría de los MMV se registraron durante la primavera; esto puede indicar una mayor abundancia de mamíferos marinos en el área durante esta temporada del año. Se observaron heridas de probable origen antropogénico en 17% (n=26) de todos los animales. La mayoría fueron Z. californianus (n=24), probablemente debido a su conocida interacción con pesquerías; 70% fueron machos.
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