Kirstin Brandt eI al.Pfe' d eh e il ku n de 13 (199 7) 2 (J an uar -Feb ru an) [27][28][29][30][31][32][33][34] Atypical Myoglobinuria in grazing horsesIn autumn 1995 for the first time horses were taken to the clinic for horses in Hannover that showed symptoms of a muscular disease, not seen so far. None of the twelve patients survived this atypical myoglobinuria although extensive treatment was performed. At the same time other veterinarians reported on 103 cases. 99 of them died. Without exception all horses and ponies were not in training and kept on pasture just before the disease set on. In most of the cases more than one horse of a srngle pasture was affected. Different breeds, sexes and age groups were concerned. In the beginning all horses showed muscular tremor, stiffness and stagger. They were dull or apathetic. Heart rates and breathing frequencies were elevated. Appetite was maintained very long and only a few horses were painful. The rectal palpation revealed only a highly filled bladder. All patients showed a massive elevation of creatine kinase and myoglobinuria was characteristic, Treatment included infusion of isotonic solutions, analgesics, anti-inflammatory agents and doses of Vitamin E/selenium. Despite intensive medical care and treatment all horses came to recumbency within three days and finally died. In pathologic anatomical examinations various muscle groups showed a marked, acute rhabdomyolysis of type I fibres. Up to this day laboratory diagnostics, clinical, pathologic-anatomical, histological and toxicologrcal findings could not reveal the etiology of atypical myoglobinurla.

Numerous laboratory parameters were examined in 235 patients with generalized psoriasis treated orally with retinoid and in 35 patients treated topically with anthralin as control. Computer evaluation of the obtained data revealed statistical trends to elevation of the total serum bilirubin level and increasing number of blood monocytes after long-term oral treatment. No other statistically significant changes of the laboratory data were found. Particularly, the liver function tests (transaminases, prothrombin and alkaline phosphatase) showed no significant alterations. Only in a few cases did the retinoid compound have an influence on the GPT and GOT levels. The reasons for this individual sensitivity to the drug remain unknown. No significant alterations were found in the control group treated topically with anthralin.

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