Routine registration of incidents yields a clinically attractive instrument of controlling safety aspects and quality measures in cardiopulmonary bypass. The observed incidence rates are somewhat higher than previously reported, probably primarily related to the methodology implemented in this study.
Cardiopulmonary bypass (CPB) with heparin coating and a reduced dose of heparin seems to be safe. Clinical outcome and neurological injury seem not to be associated with type of heparin coating used for CPB. However, blood loss and transfusion requirements may be reduced.
In this study, retransfusion of PSB during cardiac surgery appeared not to cause memory disturbances. PSB contained high concentrations of protein S100B making its use as a marker of cerebral injury unsuitable.
Ten patients admitted for coronary artery bypass grafting were investigated with respect to the influence of cardiopulmonary bypass (CPB) on red blood cell (RBC) trauma. Blood samples were collected prior to, at the start of, and at 30 and 60 min of CPB. RBC deformability was assessed by filtering re-suspended RBCs through a polycarbonate membrane using a computer-controlled filtrometer. Multiple regression analysis was employed to evaluate RBC flow-curve characteristics denoted by the initial filtration rate (IFR) and clogging slope (CS). Release of free haemoglobin was determined concomitantly. IFR was estimated at 90.39 microl/s and CS at -5.32 microl/s2 prior to CPB. During 60 min of CPB, neither IFR nor CS deviated significantly (p > 0.05) from these reference values. However, release of free haemoglobin increased significantly (p < 0.018) from the start of CPB to the 60-min determination. In conclusion, 60 min of CPB seems not to alter significantly RBC deformability in a 5 microm pore filtration model, despite a significant release of haemoglobin.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.